酸浆素I，一种从酸浆中提取的新型具有细胞毒性的睡茄内酯。
Withangulatin I, a new cytotoxic withanolide from Physalis angulata.
作者信息
Lee Shwu-Woan, Pan Min-Hsiung, Chen Chiu-Ming, Chen Zong-Tsi
机构信息
Department of Applied Chemistry, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
出版信息
Chem Pharm Bull (Tokyo). 2008 Feb;56(2):234-6. doi: 10.1248/cpb.56.234.
A new withanolide, withangulatin I (2), was isolated from the whole plant of Physalis angulata. Its structure was established as (20S,22R)-15alpha-acetoxy-5beta,6beta-epoxy-14alpha-hydroxy-1,4-dioxo-witha-2,16,24-trienolide on the basis of chemical and spectroscopic methods including 2D-NMR and circular dichroism (CD) experiments. Withangulatin A (1) and withangulatin I (2) were tested for their cytotoxic activities against two human cancer cell lines, colorectal carcinoma COLO 205 and gastric carcinoma AGS, in vitro. Compounds 1 and 2 exhibited inhibitory activities against these two human cancer cells with IC(50) values of 16.6 and 1.8 and 53.6 and 65.4 muM, respectively.
从酸浆全草中分离出一种新的维A醇内酯——酸浆内酯I（2）。基于包括二维核磁共振（2D-NMR）和圆二色性（CD）实验在内的化学和光谱方法，其结构被确定为(20S,22R)-15α-乙酰氧基-5β,6β-环氧-14α-羟基-1,4-二氧代-维A-2,16,24-三烯醇内酯。对酸浆内酯A（1）和酸浆内酯I（2）进行了体外抗两种人类癌细胞系（结肠直肠癌COLO 205和胃癌AGS）的细胞毒性活性测试。化合物1和2对这两种人类癌细胞均表现出抑制活性，其半数抑制浓度（IC50）值分别为16.6和1.8以及53.6和65.4μM。
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