Gao Caiyun, Li Ruijun, Zhou Miaomiao, Yang Yanwei, Kong Lingyi, Luo Jun
a State Key Laboratory of Natural Medicines, Department of Natural Medicinal Chemistry , China Pharmaceutical University , Nanjing , People's Republic of China.
Nat Prod Res. 2018 Mar;32(6):676-681. doi: 10.1080/14786419.2017.1338281. Epub 2017 Jun 15.
A new withanolide (1), physagulide P, together with five known withanolides (2-6), was isolated from the aerial parts of Physalis angulata L. The structure of new compound was elucidated on the basis of extensive spectroscopic techniques, including 1D, 2D NMR and HRESIMS. The activity screening indicated that compound 1 showed significant cytotoxicities against the human osteosarcoma cell line MG-63, HepG-2 hepatoma cells and breast cancer cells MDA-MB-231 with the IC value of 3.50, 4.22 and 15.74 μM.
从酸浆的地上部分分离出一种新的维A醇内酯（1），即酸浆内酯P，以及五种已知的维A醇内酯（2 - 6）。通过包括一维、二维核磁共振和高分辨电喷雾电离质谱在内的广泛光谱技术阐明了新化合物的结构。活性筛选表明，化合物1对人骨肉瘤细胞系MG - 63、HepG - 2肝癌细胞和乳腺癌细胞MDA - MB - 231具有显著的细胞毒性，IC值分别为3.50、4.22和15.74 μM。
