Lemos Iara Lopes, Macedo Maria Josiane, Machado Ana Paula da Fonseca, do Nascimento Roberto de Paula, Reguengo Lívia Mateus, Cagnon Valeria Helena Alves, Junior Mario Roberto Marostica
Laboratory of Nutrition and Metabolism, School of Food Engineering, University of Campinas, Campinas 13083-862, São Paulo, Brazil.
Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP) Campinas 13083-862, São Paulo, Brazil.
Oncoscience. 2025 May 8;12:36-51. doi: 10.18632/oncoscience.618. eCollection 2025.
Stomach cancer (SC) is the fifth most prevalent and deathly type of cancer worldwide. This is a multifactorial disease, and its development can be influenced by both genetic factors and dietary habits. On the other hand, a regular consumption of fruit and vegetables rich in bioactive compounds, such as polyphenols and flavonoids, has demonstrated anti-inflammatory, antioxidant, and chemopreventive effects on SC. Brazil, which has a vast plant diversity, appears to be a promising scenario for investigating species with potential anti-tumor action. Thus, the objective of this review is to present and discuss the chemopreventive aspects of native Brazilian species in SC. Less-explored fractions of native plants, such as açaí (), araçá-do-campo (), yellow araçá (), cacao (), coriander (), physalis (), guava (), jambu (), pitanga (), and ubaia (), have demonstrated the ability to slow down the progression of the disease, indicating suppression of cell proliferation and survival, induction of apoptosis, and regulation of the cell cycle, despite showing not mechanism of action in the great majority of these studies. Although, still little studied, Brazilian plant matrices could show a promising impact against SC.
胃癌（SC）是全球第五大常见且致命的癌症类型。这是一种多因素疾病，其发展会受到遗传因素和饮食习惯的影响。另一方面，经常食用富含生物活性化合物（如多酚和类黄酮）的水果和蔬菜，已显示出对胃癌具有抗炎、抗氧化和化学预防作用。巴西拥有丰富的植物多样性，似乎是研究具有潜在抗肿瘤作用物种的理想之地。因此，本综述的目的是介绍和讨论巴西本土物种在胃癌化学预防方面的情况。巴西本土植物中较少被研究的部分，如阿萨伊果、野草莓番荔枝、黄果番荔枝、可可、香菜、酸浆、番石榴、旱金莲、红果仔和乌拜亚树，已显示出减缓疾病进展的能力，表明其具有抑制细胞增殖和存活、诱导细胞凋亡以及调节细胞周期的作用，尽管在大多数这些研究中尚未阐明其作用机制。尽管巴西植物基质的研究仍很少，但可能对胃癌显示出有前景的影响。
