Juillerat Pascal, Pittet Valérie, Felley Christian, Mottet Christian, Froehlich Florian, Vader John-Paul, Gonvers Jean-Jacques, Michetti Pierre
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Digestion. 2007;76(2):161-8. doi: 10.1159/000111031. Epub 2008 Feb 7.
The management of Crohn's disease usually consists of a succession of short-term acute phase treatments followed by a long-term maintenance therapy. Above all the most frequent adverse events and the data on the long-term safety of the therapeutic arsenal available to the physician will be taken into consideration. The drugs described in this article include 5-ASA compounds, antibiotics (metronidazole, ciprofloxacin and rifaximin), corticosteroids (budesonide, prednisone and equivalents), thiopurines (azathioprine and 6-mercaptopurine), methotrexate, anti-tumor necrosis factor inhibitors (infliximab, adalimumab, certolizumab), natalizumab, anticalcineurin inhibitors (cyclosporine, tacrolimus) and mycophenolate mofetil.
克罗恩病的治疗通常包括一系列短期急性期治疗，随后是长期维持治疗。最重要的是，将考虑最常见的不良事件以及医生可用治疗手段的长期安全性数据。本文所述药物包括5-氨基水杨酸化合物、抗生素（甲硝唑、环丙沙星和利福昔明）、皮质类固醇（布地奈德、泼尼松及等效物）、硫唑嘌呤（硫唑嘌呤和6-巯基嘌呤）、甲氨蝶呤、抗肿瘤坏死因子抑制剂（英夫利昔单抗、阿达木单抗、赛妥珠单抗）、那他珠单抗、钙调神经磷酸酶抑制剂（环孢素、他克莫司）和霉酚酸酯。
