Domingo-Pedrol P, Rodriguez de la Serna A, Mancebo-Cortes J, Sanchez-Segura J M
Eur J Respir Dis. 1985 Aug;67(2):141-4.
A 34-year-old man, previously diagnosed as having an idiopathic diffuse glomerulonephritis, developed an acute, fulminating pulmonary disease which fulfilled clinical, radiological and physiological criteria for ARDS. He also fulfilled criteria for the diagnosis of systemic lupus erythematosus. High-dose corticosteroid therapy, artificial respiration and hemodialysis were instituted and were followed by marked clinical, radiological and physiological improvement, returning to normal 15 days after admission. We discuss here the role of immune complexes in the pathogenesis of acute pulmonary vasculitis of lupus erythematosus and suggest a role of corticosteroid pulse therapy in treating ARDS of this etiology.
一名34岁男性，此前被诊断为特发性弥漫性肾小球肾炎，现患急性暴发性肺部疾病，符合急性呼吸窘迫综合征（ARDS）的临床、影像学及生理学标准。他也符合系统性红斑狼疮的诊断标准。给予大剂量皮质类固醇治疗、人工呼吸及血液透析，随后临床、影像学及生理学均显著改善，入院15天后恢复正常。我们在此讨论免疫复合物在狼疮性急性肺血管炎发病机制中的作用，并提出皮质类固醇冲击疗法在治疗该病因所致ARDS中的作用。
