Hyun Y J, Koh S J, Chae J S, Kim J Y, Kim O Y, Lim H H, Jang Y, Park S, Ordovas Jose M, Lee J H
Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Korea.
Obesity (Silver Spring). 2008 Apr;16(4):784-9. doi: 10.1038/oby.2007.127. Epub 2008 Jan 24.
The relationship of visceral adiposity with adipocytokines and low-density lipoprotein (LDL) particle distribution and oxidation in Asian metabolically obese, normal-weight (MONW) individuals has not been evaluated. We aimed to investigate the association between visceral adiposity and adipocytokines and cardiovascular disease (CVD) risk factors in MONW Korean women with normal glucose tolerance.
We examined the metabolic characteristics of 135 non-obese (BMI <25 kg/m(2)) women aged 25-64 years. Twenty-five women (BMI <25 kg/m(2) and visceral fat adiposity (VFA) > or =100 cm(2)) were classified as MONW and 25 women (BMI <25 kg/m(2) and VFA <100 cm(2)), pair-matched for age, weight, height, and menopausal status, as control group. Plasma lipid profiles and adipocytokines were evaluated in these two groups.
MONW subjects had higher systolic (P < 0.05) and diastolic blood pressure (P < 0.005) and higher concentrations of triacylglycerol (TG) (P < 0.005), insulin (P < 0.01), and free fatty acid (FFA) (P < 0.05) than control subjects. There was no significant difference between two groups in LDL-cholesterol (LDL-C) concentrations; however, MONW subjects had smaller LDL particles (P < 0.01) and higher concentrations of oxidized LDL (ox-LDL) (P < 0.05) compared with controls. Moreover, MONW subjects had higher concentrations of tumor necrosis factor-alpha (TNF-alpha) (P < 0.05), interleukin-6 (IL-6) (P < 0.05) and leptin (P < 0.05), and lower plasma adiponectin concentrations (P < 0.05). Higher intake of saturated fat with lower ratio of polyunsaturated fatty acids (PUFAs) to saturated fatty acids (SFA) and lower fiber intake than normal subjects were found in MONW women.
We found an unfavorable inflammatory profile and a more atherogenic LDL profile in MONW female subjects even in the absence of a known CVD risk factors. Moreover, MONW consumed more saturated fat and less fiber than the control group.
亚洲代谢性肥胖正常体重（MONW）个体的内脏脂肪过多与脂肪细胞因子、低密度脂蛋白（LDL）颗粒分布及氧化之间的关系尚未得到评估。我们旨在研究糖耐量正常的韩国MONW女性的内脏脂肪过多与脂肪细胞因子及心血管疾病（CVD）危险因素之间的关联。
我们检测了135名年龄在25 - 64岁的非肥胖（BMI<25kg/m²）女性的代谢特征。25名女性（BMI<25kg/m²且内脏脂肪肥胖（VFA）≥100cm²）被归类为MONW，另外25名女性（BMI<25kg/m²且VFA<100cm²），根据年龄、体重、身高和绝经状态进行配对，作为对照组。对这两组进行血浆脂质谱和脂肪细胞因子评估。
与对照组相比，MONW受试者的收缩压（P<0.05）和舒张压（P<0.005）更高，三酰甘油（TG）（P<0.005）、胰岛素（P<0.01）和游离脂肪酸（FFA）（P<0.05）浓度更高。两组的低密度脂蛋白胆固醇（LDL-C）浓度无显著差异；然而，与对照组相比，MONW受试者的LDL颗粒更小（P<0.01），氧化LDL（ox-LDL）浓度更高（P<
