Karpova M N, Vetrile L A, Kuznetsova L V, Klishina N Yu, Trekova N A
Laboratory of Epileptogenesis and Neuroimmunopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Bull Exp Biol Med. 2007 Jun;143(6):670-2. doi: 10.1007/s10517-007-0210-z.
We studied the effect of single intraperitoneal injection of antibodies against glutamate on acute generalized epileptiform activity induced by intravenous injection of pentylenetetrazole in kindled C57Bl/6 mice. We found that in animals at various stages of kindling, administration of antibodies against glutamate in a dose of 25 mg/kg 1.5 h before testing increases the threshold of clonic seizures and tonic phase of seizures with lethal outcome and latency of seizure development, i.e. produces an antiepileptic effect.
