Kuznetsova L V, Vetrilé L A, Klishina N Iu, Karpova M N
Patol Fiziol Eksp Ter. 2011 Jul-Sep(3):21-4.
It was shown that the preliminary single i.p. injection of antibodies (AB) to glutamate (GLU) 1,5 hours prior to the first injection pentylenetetrazole (prior to the beginning of kindling) did not have an effect on latency period of appearance and the severity of convulsive reactions in the mice of C57Bl/6. The administrations of AB to GLU at the different stages of kindling animals with different severity of seizures did not have an effect on their severity. Thus, AB to GLU did not posses antiepileptic effect. However, AB to GLU posses anticonvulsive action on the acute seizures reaction, inducing an increase in the thresholds of clonic seizures and tonic phase seizures with lethal outcome as well as an extended latency period of occurrance these seizures in mice with enhanced kindling-producing convulsive readiness of the brain. This effect was revealed at the different stages of kindling in animals with the severity of seizures 2-3 and 4-5 marks. Possible to assume, that the mechanisms of chronic epileptogenesis (in this case, in the form kindling-dependent enhanced convulsive readiness of the brain) and those of the acute convulsive reaction are not similar.
结果表明，在首次注射戊四氮（点燃开始前）前1.5小时腹腔内单次注射谷氨酸（GLU）抗体（AB），对C57Bl/6小鼠惊厥反应的出现潜伏期和严重程度没有影响。在点燃动物不同严重程度癫痫发作的不同阶段给予GLU抗体，对其严重程度也没有影响。因此，GLU抗体不具有抗癫痫作用。然而，GLU抗体对急性癫痫发作反应具有抗惊厥作用，可导致阵挛性发作和致死性强直相发作阈值升高，并使脑点燃性惊厥易感性增强的小鼠这些发作的出现潜伏期延长。在癫痫发作严重程度为2 - 3级和4 - 5级的动物点燃的不同阶段均发现了这种效应。可以推测，慢性癫痫发生机制（在这种情况下，表现为脑点燃依赖性惊厥易感性增强）与急性惊厥反应机制并不相同。
