大气氨对巴比妥酸盐中毒大鼠死亡率的影响。

Effect of atmospheric ammonia on mortality rate of rats with barbiturate intoxication.

作者信息

Rejniuk V L, Schafer T V, Ovsep'yan R V, Ivnitsky J J

机构信息

Military Medical Academy, St. Petersburg.

出版信息

Bull Exp Biol Med. 2007 Jun;143(6):692-4. doi: 10.1007/s10517-007-0216-6.

DOI:10.1007/s10517-007-0216-6

PMID:18239803

Abstract

Ammonia inhalation (0.84-1.07 mg/liter, 3 h) was accompanied by a 65% increase in ammonia concentration in mixed blood of intact rats. This treatment did not cause death of intact animals, but potentiated the lethal effect of sodium thiopental and inhibited external respiration and O2 consumption in animals. The resistance of rats to the lethal effect of barbiturate tended to decrease under conditions of experimental hyperammonemia induced by intraperitoneal injection of ammonium acetate in a nonlethal dose (6 mmol/kg). Our results indicate that potentiation of the toxic effect of barbiturates by atmospheric ammonia is related to its resorptive effects.

摘要

吸入氨气（0.84 - 1.07毫克/升，持续3小时）使未受损大鼠的混合血液中氨浓度增加了65%。这种处理并未导致未受损动物死亡，但增强了硫喷妥钠的致死作用，并抑制了动物的外部呼吸和氧气消耗。在腹腔注射非致死剂量（6毫摩尔/千克）醋酸铵诱导的实验性高氨血症条件下，大鼠对巴比妥酸盐致死作用的抵抗力趋于下降。我们的结果表明，大气中的氨增强巴比妥酸盐的毒性作用与其吸收作用有关。