Rejniuk V L, Schäfer T V, Ivnitsky J J
S. M. Kirov Military Medical Academy, St. Petersburg.
Bull Exp Biol Med. 2008 Jan;145(1):15-7. doi: 10.1007/s10517-008-0018-5.
In rats with acute sodium thiopental intoxication, ammonium concentration in the caecal contents was at the lower boundary of control values, while accumulation of ammonium in lavage solution injected intraperitoneally was 50-70% accelerated. Blood ammonium level did not change 3 h after sodium thiopental injection in a dose inducing sopor, but increased 3-fold during coma modeling. Intragastric administration of gentamicin (antibiotic poorly absorbed from the gastrointestinal tract) 2-fold reduced ammonium concentration in the caecal contents and prevented hyperammoniemia during induction of barbiturate coma. Hence, increased permeability of the gastrointestinal wall for ammonium promotes the development of hyperammoniemia in rats during induction of barbiturate coma.
在急性硫喷妥钠中毒的大鼠中，盲肠内容物中的铵浓度处于对照值的下限，而腹腔注射灌洗液中铵的积累加速了50 - 70%。注射诱导嗜睡剂量的硫喷妥钠3小时后，血铵水平未发生变化，但在昏迷模型建立期间增加了3倍。胃内给予庆大霉素（一种从胃肠道吸收不良的抗生素）可使盲肠内容物中的铵浓度降低2倍，并预防巴比妥类昏迷诱导期间的高氨血症。因此，胃肠道壁对铵的通透性增加促进了巴比妥类昏迷诱导期间大鼠高氨血症的发展。
