A comparative study of stimulation of erythropoiesis during renal anemia with the preparation of antibodies against erythropoietin in ultralow doses and Recormon.

作者信息

Epshtein O I, Dygai A M, Zhdanov V V, Sergeeva S A, Zyuz'kov G N, Udut E V, Khrichkova T Yu, Simanina E V, Gur'yantseva L A, Stavrova L A, Gol'dberg E D

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Sciences, Research-and-Production Company Materia Medica Holding, Moscow.

出版信息

Bull Exp Biol Med. 2007 Jun;143(6):699-702. doi: 10.1007/s10517-007-0218-4.

DOI:10.1007/s10517-007-0218-4

PMID:18239805

Abstract

We compared the stimulatory effects of a preparation of antibodies against erythropoietin in ultralow doses (Poetam) and recombinant erythropoietin (Recormon) on erythropoiesis that was suppressed by carboplatin. Both drugs possessed high erythropoiesis-stimulating activity, which was manifested in an increase in the number of erythrokaryocytes and erythroid precursors in hemopoietic tissue and count of erythrokaryocytes and reticulocytes in the peripheral blood during postcytostatic recovery. Recormon produced a rapid and short-term stimulatory effect on the erythron. The effect of Poetam developed slowly, but persisted for a longer time.

摘要