在细胞毒性骨髓抑制期间，抗血清素药物增强促红细胞生成素对红细胞生成的刺激作用。

Potentiation of the stimulatory effect of erythropoietin on erythropoiesis by antiserotonin drug during cytostatic myelosuppression.

作者信息

Goldberg E D, Dygai A M, Skurikhin E G, Pershina O V, Minakova M Yu, Ermakova N N, Firsova T V

机构信息

Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Russia.

出版信息

Bull Exp Biol Med. 2009 Jul;148(1):45-8. doi: 10.1007/s10517-009-0625-9.

DOI:10.1007/s10517-009-0625-9

PMID:19902094

Abstract

Combined stimulatory effect of antiserotonin drug and erythropoietin on the bone marrow erythropoiesis was studied under conditions of cytostatic myelosuppression. The stimulatory effect of erythropoietin on regeneration of the hemopoietic erythroid stem increased, if serotonin mediation in the CNS was disordered before induction of cytostatic myelosuppression. The stimulatory effect of a combination of cyproheptadine and epocrine (experimental group) significantly surpassed that of cyproheptadine and epocrine monotherapies. The increase in the content of erythroid elements in the blood system of experimental animals was due to recovery of the structural and functional integrity of the hemopoietic tissue (at the expense of reduction of the suppressive effect of CNS serotonin on the formation of erythroid hemopoietic islets) and simultaneous stimulation of division and maturation of erythroid precursors with epocrine.

摘要

在细胞毒性骨髓抑制条件下，研究了抗血清素药物和促红细胞生成素对骨髓红细胞生成的联合刺激作用。如果在诱导细胞毒性骨髓抑制之前中枢神经系统中的血清素介导紊乱，促红细胞生成素对造血红系干细胞再生的刺激作用会增强。赛庚啶和促分泌素联合使用（实验组）的刺激作用明显超过赛庚啶和促分泌素单一疗法。实验动物血液系统中红系成分含量的增加是由于造血组织结构和功能完整性的恢复（这是以中枢神经系统血清素对红系造血岛形成的抑制作用降低为代价的）以及促分泌素同时刺激红系前体细胞的分裂和成熟。