[DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex].
作者信息
Li P H, Pang Y H
机构信息
Physical Chemistry Department, School of Pharmaceutical Sciences, Beijing Medical University.
出版信息
Yao Xue Xue Bao. 1991;26(11):871-5.
PMID:1823983
Abstract
Effects of various factors on the DNA-breaking action of ascorbic acid in the presence of Cu(II)/demethylcantharic acid complex were studied in phosphate buffer (pH 7.40), at 37.0 +/- 0.1 degrees C. It was shown that .OH produced from Fenton reaction of H2O2 which can be formed from the oxidation of ascorbic acid was responsible for the DNA-breaking action of ascorbic acid and the simple Fenton reaction cannot explain all the results.
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