Van Kammen D P, Murphy D L
Psychopharmacologia. 1975 Nov 21;44(3):215-24. doi: 10.1007/BF00428897.
Seven of nine depressed patients experienced a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study. d-Amphetamine was 2 to 2.3-fold more effective in producing activation, euphoria, and antidepressant effects than the same dose of l-amphetamine. Co-treatment with lithium carbonate produced a 60% (P less than 0.001) attenuation of the activation and euphoria responses to d-amphetamine. The responses to l-amphetamine were almost completely abolished by lithium. This study raises the possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction.
在一项重复给药、双盲研究中，9名抑郁症患者中有7名在服用30毫克右旋苯丙胺后，欣快感评分和活动水平增加了4.3倍。右旋苯丙胺在产生兴奋、欣快感和抗抑郁作用方面比相同剂量的左旋苯丙胺有效2至2.3倍。与碳酸锂联合治疗使右旋苯丙胺引起的兴奋和欣快感反应减弱了60%（P<0.001）。碳酸锂几乎完全消除了对左旋苯丙胺的反应。这项研究提出了碳酸锂作为苯丙胺成瘾治疗辅助药物的可能性。
