van Kammen D P, Docherty J P, Marder S R, Bunney W E
Psychiatry Res. 1981 Jun;4(3):313-25. doi: 10.1016/0165-1781(81)90033-0.
Acute behavioral changes following a 20 mg i.v. d-amphetamine predicted the small antipsychotic and antidepressant effects of the third week of lithium treatment in schizophrenic patients. Multivariate regression models accounted for 95% of the variance predicting the antipsychotic effects and for 89% of the variance predicting the antidepressant effects in postpsychotic depressed patients. The greater the increases in the d-amphetamine-induced changes in the thought disorder cluster of the Brief Psychiatric Rating Scale, the greater the antipsychotic effects of lithium. The data suggest that the modest behavioral changes observed with lithium in schizophrenia are most likely drug-induced.
静脉注射20毫克右旋苯丙胺后出现的急性行为变化，可预测锂盐治疗第三周对精神分裂症患者的小剂量抗精神病和抗抑郁作用。多变量回归模型解释了预测抗精神病作用的95%的方差以及预测精神病后抑郁患者抗抑郁作用的89%的方差。简明精神病评定量表思维障碍集群中，右旋苯丙胺诱导的变化增加幅度越大，锂盐的抗精神病作用就越强。数据表明，锂盐在精神分裂症中观察到的适度行为变化很可能是药物引起的。
