马丘波病毒在灵长类动物中的感染发病机制。
Pathogenesis of Machupo virus infection in primates.
作者信息
Eddy G A, Scott S K, Wagner F S, Brand O M
出版信息
Bull World Health Organ. 1975;52(4-6):517-21.
Abstract
Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.
摘要
对恒河猴和食蟹猴进行马丘波病毒实验性感染，引发了一种严重疾病，包括初始临床阶段和随后的神经阶段。两个阶段的累计死亡率分别为80%和95%。试图通过去补体或免疫抑制来改变发病机制，导致猴子更早死亡。
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