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[婴儿特应性皮炎并非由食物过敏引起]

[Atopic dermatitis in infants not caused by food allergy].

作者信息

Wensink M, Timmer C, Brand P L P

机构信息

Isala klinieken, Amalia Kinderafdeling, Postbus 10.400, 8000 GK Zwolle.

出版信息

Ned Tijdschr Geneeskd. 2008 Jan 5;152(1):4-9.

Abstract

Food allergy is not the primary cause ofatopic dermatitis. This is illustrated in 3 patients with atopic dermatitis, a girl aged 6 months and 2 boys aged 6 and 7 months, respectively, who were referred to our outpatient clinic for evaluation for possible food allergies. All 3 patients were receiving hypoallergenic formula because their parents or health care providers suspected that the atopic dermatitis was caused by a cows' milk allergy. After sufficient explanation of the causes of atopic dermatitis and thorough clarification and use of topical therapy, a remarkable improvement in the severity of the atopic dermatitis was noted. Only 1 patient was allergic to cows' milk as confirmed by a double-blind, placebo-controlled food challenge, but there was no association with the level of eczema activity. It is a common misconception that food allergies and atopic dermatitis are always causally related. In recent years it has become clear that atopic dermatitis may result from defective skin barrier function, for which topical treatment is essential. Unjustified focus on food allergies as the primary cause ofatopic dermatitis increases the risk of unnecessary elimination diets and malnutrition. Only infants with acute allergic symptoms directly related to ingestion, i.e. urticaria and gastrointestinal symptoms, should be evaluated for food allergies by a double-blind, placebo-controlled food challenge.

摘要

食物过敏并非特应性皮炎的主要病因。这在3例特应性皮炎患者中得到了体现,分别是一名6个月大的女孩和两名6个月及7个月大的男孩,他们因可能存在食物过敏而被转诊至我们的门诊进行评估。所有3例患者均接受低敏配方奶粉喂养,因为他们的父母或医疗服务提供者怀疑特应性皮炎是由牛奶过敏引起的。在对特应性皮炎的病因进行充分解释、彻底澄清并采用局部治疗后,特应性皮炎的严重程度有了显著改善。经双盲、安慰剂对照食物激发试验证实,只有1例患者对牛奶过敏,但这与湿疹活动程度并无关联。食物过敏与特应性皮炎总是因果相关,这是一种常见的误解。近年来已经明确,特应性皮炎可能是由皮肤屏障功能缺陷所致,对此局部治疗至关重要。将食物过敏无端地视为特应性皮炎的主要病因,会增加不必要的饮食限制和营养不良的风险。只有那些出现与摄入直接相关的急性过敏症状(即荨麻疹和胃肠道症状)的婴儿,才应通过双盲、安慰剂对照食物激发试验来评估食物过敏情况。

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