Businco L, Benincori N, Nini G, Businco E, Cantani A, De Angelis M
Ann Allergy. 1986 Dec;57(6):433-8.
Thirty-one children with atopic dermatitis, aged 6 months to 10 years, were selected for this trial. All had historical, clinical, and laboratory evidences that allergy to food was the cause of exacerbations of eczema. Either oral sodium cromoglycate (SCG) or a matching placebo was administered orally for 8 weeks, followed by the alternative treatment for a further 8-week period. During the first 4 weeks of each treatment period, patients remained on an exclusion diet. During the second 4 weeks, the offending food(s) was reintroduced into the diet. The severity of the eczema and the changes in severity as a result of diet or challenge were measured both by the clinician (using body diagrams) and by parents (using a daily diary card). Analysis of the clinician's scoring and the patient's diary card scores demonstrated a statistically significant difference in favour of SCG, especially in the group where the placebo preceded the active treatment. Sodium cromoglycate does seem to reduce the exacerbations of atopic dermatitis caused by food allergens.
本试验选取了31名患有特应性皮炎的儿童，年龄在6个月至10岁之间。所有患儿均有病史、临床及实验室证据表明食物过敏是湿疹加重的原因。口服色甘酸钠（SCG）或匹配的安慰剂，为期8周，之后再进行8周的交替治疗。在每个治疗期的前4周，患者维持排除特定食物的饮食。在第二个4周，将引起过敏的食物重新引入饮食中。湿疹的严重程度以及饮食或激发试验导致的严重程度变化，由临床医生（使用身体图表）和家长（使用每日日记卡）进行测量。对临床医生评分和患者日记卡评分的分析表明，色甘酸钠组在统计学上有显著差异，尤其在安慰剂治疗先于活性治疗的组中。色甘酸钠似乎确实能减少由食物过敏原引起的特应性皮炎加重情况。
