Koponen H, Mäki P, Halonen H, Miettunen J, Laitinen J, Tammelin T, Moilanen I, Taanila A, Ruokonen A, Korkeila J, Veijola J
Department of Psychiatry, University of Kuopio, and Academy of Finland, Kuopio, Finland.
Acta Psychiatr Scand. 2008 May;117(5):337-41. doi: 10.1111/j.1600-0447.2008.01154.x. Epub 2008 Jan 30.
Type 2 diabetes and dyslipidemias co-occur frequently with schizophrenia. It is not known how common they are in adolescents with a familial risk for psychosis.
The Northern Finland 1986 Birth Cohort consists of 9432 children born alive in the two Northernmost provinces in Finland. At the age of 15/16 they participated in clinical examination including measurements of glucose, lipids and IR, and a questionnaire including items about their diet and physical activity. The Finnish Hospital Discharge Register was used to find out non-organic psychoses in parents during 1972-2000. This familial risk was found out in 54 boys and 68 girls. Their results were compared with other cohort members.
No differences were observed in the cardiometabolic risk factors between the study groups.
Our results suggest that familial risk for psychosis is not directly associated with disturbances of glucose and lipid metabolism among adolescents.
2型糖尿病和血脂异常常与精神分裂症同时出现。目前尚不清楚它们在有精神病家族风险的青少年中有多常见。
芬兰北部1986年出生队列包括在芬兰最北部两个省份出生的9432名活产儿童。在15/16岁时，他们参加了临床检查，包括测量血糖、血脂和胰岛素抵抗，以及一份关于饮食和体育活动的问卷。利用芬兰医院出院登记册查找1972 - 2000年间父母的非器质性精神病情况。在54名男孩和68名女孩中发现了这种家族风险。他们的结果与其他队列成员进行了比较。
研究组之间在心脏代谢危险因素方面未观察到差异。
我们的结果表明，青少年精神病家族风险与糖脂代谢紊乱无直接关联。
