Protsenko Maria, Kerkelä Martta, Miettunen Jouko, Auvinen Juha, Järvelin Marjo-Riitta, Jones Peter B, Gissler Mika, Veijola Juha
Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland.
Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu, Finland.
Schizophr Res. 2023 Feb;252:271-278. doi: 10.1016/j.schres.2023.01.013. Epub 2023 Jan 23.
Type 2 diabetes and dyslipidemias co-occur frequently with severe mental illnesses (SMI). However, less is known about serum insulin and lipid levels and prevalence of Insulin Resistance (IR) in offspring with familial risk for SMI.
The Northern Finland Birth Cohort 1966 consists of 12,068 mothers, 11,068 fathers, and 12,231 children from the two northernmost provinces in Finland. At age 46 they participated in clinical examination including measurements of glucose, lipids, and IR and answered a questionnaire including information about their nutrition and physical activity. The information on parental SMI was obtained from the Hospital Discharge Register. Parents with SMI were those who had been treated in hospital for any psychiatric disorder during 1969-1982 (ICD-8 codes 290-315). The final study group included 334 (7.3 %) offspring who had a parent with SMI and 4249 (92.7 %) offspring in the comparison group.
We did not find increased risk for disturbances in lipid levels, insulin levels, or IR levels between the study group (offspring of either parent with SMI) compared with the comparison group. All offspring, especially female offspring of either parent with SMI, had an increased risk for higher glucose levels and waist circumference. The results remained the same after excluding offspring with SMI.
Our findings suggest that offspring of parents with SMI, especially female offspring, have partly increased risk for disturbances in cardiometabolic risk factors. Disturbances in glucose metabolism may have an effect via familial risk of severe mental illness.
2型糖尿病和血脂异常常与严重精神疾病（SMI）同时出现。然而，对于有SMI家族风险的后代，血清胰岛素和血脂水平以及胰岛素抵抗（IR）的患病率了解较少。
1966年芬兰北部出生队列包括来自芬兰最北部两个省份的12068名母亲、11068名父亲和12231名儿童。在46岁时，他们参加了临床检查，包括测量血糖、血脂和IR，并回答了一份关于他们营养和身体活动的问卷。父母SMI的信息来自医院出院登记册。患有SMI的父母是指在1969 - 1982年期间因任何精神疾病在医院接受治疗的人（国际疾病分类第8版代码290 - 315）。最终研究组包括334名（7.3%）有SMI父母的后代和4249名（92.7%）对照组后代。
我们发现，与对照组相比，研究组（有SMI父母的任何一方的后代）在血脂水平、胰岛素水平或IR水平方面没有发现风险增加。所有后代，尤其是有SMI父母的任何一方的女性后代，血糖水平升高和腰围增加的风险增加。排除患有SMI的后代后，结果仍然相同。
我们的研究结果表明，有SMI父母的后代，尤其是女性后代，在心脏代谢危险因素方面出现紊乱的风险部分增加。葡萄糖代谢紊乱可能通过严重精神疾病的家族风险产生影响。
