急性髓系白血病

Acute myeloid leukemia.

作者信息

Rubnitz Jeffrey E, Gibson Brenda, Smith Franklin O

机构信息

Department of Oncology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

出版信息

Pediatr Clin North Am. 2008 Feb;55(1):21-51, ix. doi: 10.1016/j.pcl.2007.11.003.

DOI:10.1016/j.pcl.2007.11.003

PMID:18242314

Abstract

Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from clonal transformation of hematopoietic precursors through the acquisition of chromosomal rearrangements and multiple gene mutations. As a result of highly collaborative clinical research by pediatric cooperative cancer groups worldwide, disease-free survival has improved significantly during the past 3 decades. Further improvements in outcomes of children who have AML probably will reflect continued progress in understanding the biology of AML and the concomitant development of new molecularly targeted agents for use in combination with conventional chemotherapy drugs.

摘要

急性髓系白血病（AML）是一组异质性白血病，由造血前体细胞通过获得染色体重排和多个基因突变而发生克隆性转化所致。由于全球儿科癌症协作组开展的高度协作的临床研究，在过去30年中，无病生存率有了显著提高。AML患儿治疗效果的进一步改善可能将反映在对AML生物学认识的持续进展以及与传统化疗药物联合使用的新型分子靶向药物的同步研发上。