外周大麻素可减轻小鼠体内癌诱导的伤害感受。
Peripheral cannabinoids attenuate carcinoma-induced nociception in mice.
作者信息
Guerrero Andre V, Quang Phuong, Dekker Nusi, Jordan Richard C K, Schmidt Brian L
机构信息
UCSF School of Dentistry, University of California, Sa Francisco, CA 94143-0440, United States.
出版信息
Neurosci Lett. 2008 Mar 12;433(2):77-81. doi: 10.1016/j.neulet.2007.12.053. Epub 2008 Jan 8.
We investigated the cannabinoid receptor (CBr) agonists Win55,212-2 (non-selective) and AM1241 (CBr2 selective) and the peripheral receptor (CBr1) in carcinoma-induced pain using a mouse model. Tumors were induced in the hind paw of female mice by local injection of a human oral squamous cell carcinoma (SCC). Significant pain, as indicated by reduction in withdrawal thresholds in response to mechanical stimulation, began at 4 days after SCC inoculation and lasted to 18 days. Local administration of Win55,212-2 (10 mg/kg) and AM1241 (10 mg/kg) significantly elevated withdrawal thresholds, indicating an antinociceptive effect. Ipsilateral expression of CBr1 protein in L5 DRG was significantly upregulated compared to ipsilateral L4 DRG and in normal tissue. These findings support the suggestion that cannabinoids are capable of producing antinociception in carcinoma-induced pain.
我们使用小鼠模型研究了大麻素受体（CBr）激动剂Win55,212-2（非选择性）和AM1241（CBr2选择性）以及外周受体（CBr1）在癌痛中的作用。通过局部注射人口腔鳞状细胞癌（SCC）在雌性小鼠后爪诱导肿瘤。接种SCC后4天开始出现明显疼痛，表现为对机械刺激的撤针阈值降低，并持续至18天。局部给予Win55,212-2（10mg/kg）和AM1241（10mg/kg）可显著提高撤针阈值，表明具有抗伤害感受作用。与同侧L4背根神经节（DRG）和正常组织相比，L5 DRG中CBr1蛋白的同侧表达显著上调。这些发现支持了大麻素能够在癌痛中产生抗伤害感受的观点。
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