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Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.花生四烯乙醇胺和Δ9-四氢大麻酚通过CB2受体直接抑制免疫系统细胞。
J Neuroimmunol. 2007 Sep;189(1-2):17-22. doi: 10.1016/j.jneuroim.2007.06.001. Epub 2007 Jul 19.
2
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Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors.内源性大麻素通过 CB2 受体主要抑制原代人 T 淋巴细胞的增殖和细胞因子释放。
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Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.在恒河猴辨别Δ9-四氢大麻酚的实验中，利莫那班与花生四烯乙醇胺及其化学类似物联合使用时的表观亲和力估计值。
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Anandamide effects on 5-HT(3) receptors in vivo.花生四烯乙醇胺对体内5-羟色胺（3）受体的影响。
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Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond.作用于大脑中大麻素受体的配体：从四氢大麻酚到花生四烯乙醇胺及其他。
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Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride].花生四烯酸乙醇胺和Δ⁹-四氢大麻酚诱发的花生四烯酸动员以及SR141716A [盐酸N-(哌啶-1-基)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-1H-吡唑-3-甲酰胺]的阻断作用
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Cannabinoids and the human uterus during pregnancy.孕期大麻素与人类子宫
Am J Obstet Gynecol. 2004 Jan;190(1):2-9; discussion 3A. doi: 10.1016/j.ajog.2003.07.013.
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Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8 T and NK cells.大麻素受体 2 通过限制 CD8 T 和 NK 细胞的抗肿瘤活性在非小细胞肺癌中发挥促肿瘤作用。
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Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2.大麻通过 CNR2 抑制 T 细胞中的 JAK/STAT 信号传导来抑制抗肿瘤免疫。
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本文引用的文献

1
Cannabinoid treatment suppresses the T-helper cell-polarizing function of mouse dendritic cells stimulated with Legionella pneumophila infection.大麻素治疗可抑制由嗜肺军团菌感染刺激的小鼠树突状细胞的辅助性T细胞极化功能。
J Pharmacol Exp Ther. 2006 Oct;319(1):269-76. doi: 10.1124/jpet.106.108381. Epub 2006 Jul 12.
2
Pharmacological actions of cannabinoids.大麻素的药理作用。
Handb Exp Pharmacol. 2005(168):1-51. doi: 10.1007/3-540-26573-2_1.
3
Cannabinoid receptors in microglia of the central nervous system: immune functional relevance.中枢神经系统小胶质细胞中的大麻素受体：免疫功能相关性
J Leukoc Biol. 2005 Dec;78(6):1192-7. doi: 10.1189/jlb.0405216. Epub 2005 Oct 4.
4
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.大麻素CB1受体的反向激动作用和中性拮抗作用。
Life Sci. 2005 Feb 4;76(12):1307-24. doi: 10.1016/j.lfs.2004.10.025. Epub 2004 Dec 8.
5
Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation.通过树突状细胞上的大麻素受体1和2激活会触发核因子κB依赖性凋亡：内源性和外源性大麻素在免疫调节中的新作用。
J Immunol. 2004 Aug 15;173(4):2373-82. doi: 10.4049/jimmunol.173.4.2373.
6
Anandamide is an endogenous inhibitor for the migration of tumor cells and T lymphocytes.花生四烯乙醇胺是肿瘤细胞和T淋巴细胞迁移的内源性抑制剂。
Cancer Immunol Immunother. 2004 Aug;53(8):723-8. doi: 10.1007/s00262-004-0509-9. Epub 2004 Mar 18.
7
Pharmacological characterisation of cannabinoid receptors inhibiting interleukin 2 release from human peripheral blood mononuclear cells.抑制人外周血单核细胞释放白细胞介素2的大麻素受体的药理学特性
Eur J Pharmacol. 2003 Mar 19;464(2-3):207-15. doi: 10.1016/s0014-2999(03)01379-7.
8
Cannabinol enhancement of interleukin-2 (IL-2) expression by T cells is associated with an increase in IL-2 distal nuclear factor of activated T cell activity.大麻酚增强T细胞白细胞介素-2（IL-2）的表达与活化T细胞核因子IL-2远端活性增加有关。
Mol Pharmacol. 2002 Feb;61(2):446-54. doi: 10.1124/mol.61.2.446.
9
Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation.啮齿动物巨噬细胞和巨噬样细胞中CB2大麻素受体的差异表达与细胞活化的关系。
Int Immunopharmacol. 2002 Jan;2(1):69-82. doi: 10.1016/s1567-5769(01)00147-3.
10
Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.大麻素对脂多糖刺激巨噬细胞释放炎性介质的影响：类花生酸的作用
J Cell Biochem. 2001;81(4):715-23. doi: 10.1002/jcb.1103.

花生四烯乙醇胺和Δ9-四氢大麻酚通过CB2受体直接抑制免疫系统细胞。

Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.

作者信息

Eisenstein Toby K, Meissler Joseph J, Wilson Qiana, Gaughan John P, Adler Martin W

机构信息

Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States.

出版信息

J Neuroimmunol. 2007 Sep;189(1-2):17-22. doi: 10.1016/j.jneuroim.2007.06.001. Epub 2007 Jul 19.

DOI:10.1016/j.jneuroim.2007.06.001
PMID:17640739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2083705/
Abstract

This study shows that two cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and anandamide, induce dose-related immunosuppression in both the primary and secondary in vitro plaque-forming cell assays of antibody formation. The immunosuppression induced by both compounds could be blocked by SR144528, an antagonist specific for the CB(2) receptor, but not by SR141716, a CB(1) antagonist. These studies are novel in that they show that both anandamide and THC are active in the nanomolar to picomolar (for anandamide) range in these assays of immune function, and that both mediate their effects directly on cells of the immune system through the CB(2) receptor.

摘要

本研究表明，两种大麻素，即Δ⁹-四氢大麻酚（THC）和花生四烯酸乙醇胺，在抗体形成的体外初次和二次空斑形成细胞试验中均诱导剂量相关的免疫抑制。这两种化合物诱导的免疫抑制可被CB₂受体特异性拮抗剂SR144528阻断，但不能被CB₁拮抗剂SR141716阻断。这些研究具有新颖性，因为它们表明在这些免疫功能试验中，花生四烯酸乙醇胺和THC在纳摩尔至皮摩尔（针对花生四烯酸乙醇胺）范围内均具有活性，并且二者均通过CB₂受体直接介导其对免疫系统细胞的作用。