花生四烯乙醇胺和Δ9-四氢大麻酚通过CB2受体直接抑制免疫系统细胞。
Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.
作者信息
Eisenstein Toby K, Meissler Joseph J, Wilson Qiana, Gaughan John P, Adler Martin W
机构信息
Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA 19140, United States.
出版信息
J Neuroimmunol. 2007 Sep;189(1-2):17-22. doi: 10.1016/j.jneuroim.2007.06.001. Epub 2007 Jul 19.
Abstract
This study shows that two cannabinoids, Delta(9)-tetrahydrocannabinol (THC) and anandamide, induce dose-related immunosuppression in both the primary and secondary in vitro plaque-forming cell assays of antibody formation. The immunosuppression induced by both compounds could be blocked by SR144528, an antagonist specific for the CB(2) receptor, but not by SR141716, a CB(1) antagonist. These studies are novel in that they show that both anandamide and THC are active in the nanomolar to picomolar (for anandamide) range in these assays of immune function, and that both mediate their effects directly on cells of the immune system through the CB(2) receptor.
摘要
本研究表明，两种大麻素，即Δ⁹-四氢大麻酚（THC）和花生四烯酸乙醇胺，在抗体形成的体外初次和二次空斑形成细胞试验中均诱导剂量相关的免疫抑制。这两种化合物诱导的免疫抑制可被CB₂受体特异性拮抗剂SR144528阻断，但不能被CB₁拮抗剂SR141716阻断。这些研究具有新颖性，因为它们表明在这些免疫功能试验中，花生四烯酸乙醇胺和THC在纳摩尔至皮摩尔（针对花生四烯酸乙醇胺）范围内均具有活性，并且二者均通过CB₂受体直接介导其对免疫系统细胞的作用。
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