Synthesis of potent pyrrolidine influenza neuraminidase inhibitors.
作者信息
Krueger A Chris, Xu Yibo, Kati Warren M, Kempf Dale J, Maring Clarence J, McDaniel Keith F, Molla Akhteruzzaman, Montgomery Debra, Kohlbrenner William E
机构信息
Infectious Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 200 Abbott Park Road, AP-52N, Abbott Park, IL 60064, USA.
出版信息
Bioorg Med Chem Lett. 2008 Mar 1;18(5):1692-5. doi: 10.1016/j.bmcl.2008.01.048. Epub 2008 Jan 18.
PMID:18242993
Abstract
The synthesis of several pyrrolidine inhibitor analogs is described that possess nanomolar in vitro potencies against the neuraminidase enzymes expressed by the B/Memphis/3/89 and A/N1/PR/8/34 influenza strains.
摘要
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