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用于治疗病毒性肺炎的中医药:药理基础与作用机制洞察

Traditional Chinese Medicine for Viral Pneumonia Therapy: Pharmacological Basis and Mechanistic Insights.

作者信息

Bai Yinglu, Liu Tengwen, Zhang Shuwen, Shi Yifan, Yang Yumei, Ding Maoyu, Yang Xiaowei, Guo Shanshan, Xu Xiaolong, Liu Qingquan

机构信息

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.

Beijing Institute of Chinese Medicine, Beijing 100010, China.

出版信息

Int J Biol Sci. 2025 Jan 6;21(3):989-1013. doi: 10.7150/ijbs.105086. eCollection 2025.

Abstract

Different respiratory viruses might cause similar symptoms, ranging from mild upper respiratory tract involvement to severe respiratory distress, which can rapidly progress to septic shock, coagulation disorders, and multiorgan failure, ultimately leading to death. The COVID-19 pandemic has shown that predicting clinical outcomes can be challenging because of the complex interactions between the virus and the host. Traditional Chinese medicine (TCM) has distinct benefits in the treatment of respiratory viral illnesses due to its adherence to the principles of "different treatments for the same disease" and "same treatment for different diseases". This paper examines the effectiveness and underlying mechanisms of key TCM treatments for viral pneumonia in recent years. The aim of this study was to discover and confirm the active substances of TCM with potential therapeutic effects on viral pneumonia and their integrative effects and synergistic mechanisms and to provide a scientific basis for elucidating the effectiveness of TCM treatment and drug discovery. Furthermore, a thorough analysis of previous research is necessary to evaluate the effectiveness of TCM in treating viral pneumonia.

摘要

不同的呼吸道病毒可能引发相似的症状,从轻微的上呼吸道感染到严重的呼吸窘迫,后者可迅速发展为感染性休克、凝血功能障碍和多器官衰竭,最终导致死亡。2019冠状病毒病大流行表明,由于病毒与宿主之间复杂的相互作用,预测临床结果可能具有挑战性。传统中医(TCM)在治疗呼吸道病毒性疾病方面具有独特优势,因其遵循“同病异治”和“异病同治”的原则。本文探讨了近年来中医治疗病毒性肺炎的关键疗法的有效性及潜在机制。本研究的目的是发现并确认对病毒性肺炎具有潜在治疗作用的中药活性物质及其综合作用和协同机制,为阐明中医治疗的有效性和药物研发提供科学依据。此外,有必要对以往的研究进行全面分析,以评估中医治疗病毒性肺炎的有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d5/11781171/794623cfe21d/ijbsv21p0989g001.jpg

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