Guarente Leonard
Department of Biology, Massachusetts Institute of Technology, Cambridge MA 02139, USA.
Cell. 2008 Jan 25;132(2):171-6. doi: 10.1016/j.cell.2008.01.007.
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
最近对几种生物进行的卡路里限制研究表明,线粒体活性增加,这与这种饮食限制方案的有益效果相关。在这篇文章中,我推测线粒体活性增加可能如何带来益处,并讨论饮食、线粒体和去乙酰化酶可能如何在延缓衰老及相关疾病的途径中相互作用。