Qiu Xiaolei, Brown Katharine V, Moran Yehu, Chen Danica
Department of Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.
Biochim Biophys Acta. 2010 Aug;1804(8):1576-83. doi: 10.1016/j.bbapap.2009.09.015. Epub 2009 Sep 24.
The beneficial effects of calorie restriction diet in extending lifespan and preventing diseases have long been recognized. Recent genetic and molecular studies in model organisms began to uncover the molecular regulation of calorie restriction response, with the gene SIR2 playing an essential role. This article summarizes the latest development on how mammalian SIR2 homologs coordinately regulate the calorie restriction response.
长期以来，人们一直认识到热量限制饮食在延长寿命和预防疾病方面的有益作用。最近在模式生物中进行的基因和分子研究开始揭示热量限制反应的分子调控机制，其中基因SIR2起着至关重要的作用。本文总结了关于哺乳动物SIR2同源物如何协同调节热量限制反应的最新进展。
