成年胰腺中的兼性内分泌祖细胞。

Facultative endocrine progenitor cells in the adult pancreas.

作者信息

Dor Yuval, Melton Douglas A

机构信息

Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

出版信息

Cell. 2008 Jan 25;132(2):183-4. doi: 10.1016/j.cell.2008.01.004.

DOI:10.1016/j.cell.2008.01.004

PMID:18243094

Abstract

Using a unique injury model of the pancreas in mouse, Xu et al. (2008) now reveal the involvement of neurogenin3, a marker for embryonic-type endocrine progenitor cells, in the formation of new insulin-producing beta cells. These neurogenin3-positive facultative endocrine progenitor cells in the adult pancreas may be of potential value for treating diabetes.

摘要

徐等人（2008年）利用一种独特的小鼠胰腺损伤模型，揭示了神经生成素3（一种胚胎型内分泌祖细胞的标志物）在新的产生胰岛素的β细胞形成过程中的作用。成年胰腺中这些神经生成素3阳性的兼性内分泌祖细胞对于治疗糖尿病可能具有潜在价值。