成年胰腺腺泡祖细胞样群体在再生和癌症中的作用。
Adult Pancreatic Acinar Progenitor-like Populations in Regeneration and Cancer.
机构信息
Division of Digestive and Liver Disease, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Division of Hematology and Oncology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
出版信息
Trends Mol Med. 2020 Aug;26(8):758-767. doi: 10.1016/j.molmed.2020.04.003. Epub 2020 Apr 30.
The bulk of the pancreas primarily comprises long-lived acinar cells that are not considered a bona fide source for stem cells. However, certain acinar subpopulations have a repopulating capacity during regeneration, raising the hypothesis as to the presence of regenerative progenitor-like populations in the adult pancreas. Here, we describe recent discoveries based on fate-mapping techniques that support the existence of progenitor-like acinar subpopulations, including active progenitor-like cells that maintain tissue homeostasis and facultative progenitor-like cells that drive tissue regeneration. A possible link between progenitor-like acinar cells and cancer initiators is proposed. Further analysis of these cellular components is needed, because it would help uncover possible cellular sources for regeneration and cancer, as well as potential targets for therapy.
胰腺的大部分主要由长寿的腺泡细胞组成，这些细胞不被认为是真正的干细胞来源。然而，某些腺泡亚群在再生过程中有再殖能力，这就提出了在成年胰腺中存在再生祖细胞样群体的假说。在这里，我们描述了基于谱系追踪技术的最新发现，这些发现支持了祖细胞样腺泡亚群的存在，包括维持组织内稳态的活跃祖细胞样细胞和驱动组织再生的兼性祖细胞样细胞。提出了祖细胞样腺泡细胞与癌症启动子之间可能存在的联系。需要进一步分析这些细胞成分，因为这将有助于发现可能的再生和癌症的细胞来源，以及可能的治疗靶点。
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