Mølhave L
Institute of Environmental and Occupational Medicine, University of Aarhus, Denmark.
J Expo Anal Environ Epidemiol. 1991 Jan;1(1):63-81.
The term sick building syndrome (SBS) is frequently used to describe a set of symptoms often reported by occupants of certain buildings. The symptoms are supposed to be direct or indirect consequences of an inadequate indoor climate. Typically, a majority of the occupants in these buildings complain, and the most frequent complaint is irritation of eyes, nose, and throat. Many different factors are known to be potential agents for the symptoms and no definitive causality has been identified yet. In consequence authors of publications on indoor air quality have been using the SBS term in different ways. A review of literature indicates that in supposed "sick buildings" only the prevalence of irritation of mucosal membranes and headaches seems to differ significantly from the prevalence in buildings considered to have a normal indoor climate. Volatile organic compounds (VOC) are known to have a potency to cause symptoms like those included in SBS. A dose-response relation for sensory reactions and mucosal irritation caused by volatile organic air pollutants is discussed, and a tentative guideline at 3 mg/m3 (about 0.9 PPM toluene equivalent) for the total volatile organic compounds (TVOC) is suggested for the nonindustrial indoor climates.
“病态建筑综合征”（SBS）一词常被用于描述某些建筑物内居住者经常报告的一系列症状。这些症状被认为是室内气候不佳的直接或间接后果。通常，这些建筑物中的大多数居住者都会抱怨，最常见的抱怨是眼睛、鼻子和喉咙受到刺激。已知许多不同因素可能是导致这些症状的原因，但尚未确定明确的因果关系。因此，关于室内空气质量的出版物作者对SBS一词的使用方式各不相同。文献综述表明，在所谓的“病态建筑”中，只有粘膜刺激和头痛的发生率似乎与被认为室内气候正常的建筑物有显著差异。已知挥发性有机化合物（VOC）有引发类似SBS症状的可能性。讨论了挥发性有机空气污染物引起的感官反应和粘膜刺激的剂量反应关系，并针对非工业室内环境，建议将总挥发性有机化合物（TVOC）的暂定指导值设定为3毫克/立方米（约0.9 ppm甲苯当量）。
