Yoo Choung Ryong, Yeo In-Sung, Park Ko Eun, Park Ji Hun, Lee Seung Jin, Park Won Ho, Min Byung-Moo
Department of Oral Biochemistry and Craniomaxillofacial Reconstructive Science, Dental Research Institute, and BK21 CLS, Seoul National University School of Dentistry, 28 Yeonkun-Dong, Chongno-Ku, Seoul 110-749, Republic of Korea.
Int J Biol Macromol. 2008 May 1;42(4):324-34. doi: 10.1016/j.ijbiomac.2007.12.004. Epub 2007 Dec 25.
To fabricate a biomimetic nanostructured bicomponent scaffolds, two types of chitin/silk fibroin (SF) nanofibrous scaffolds (blend scaffolds and hybrid scaffolds) were prepared by electrospinning or simultaneous electrospinning of chitin/SF solutions. The chitin/SF bicomponent scaffolds were after-treated with water vapor, and their nanofibrous structures were almost maintained. From the cytocompatibility and cell behavior on the chitin/SF blend or hybrid nanofibrous scaffolds, the hybrid matrix with 25% chitin and 75% SF as well as the chitin/SF blend nanofibers could be a potential candidate for tissue engineering scaffolds.
为制备一种仿生纳米结构双组分支架，通过对几丁质/丝素蛋白（SF）溶液进行静电纺丝或同时静电纺丝，制备了两种类型的几丁质/丝素蛋白纳米纤维支架（共混支架和混合支架）。几丁质/SF双组分支架经水蒸气后处理，其纳米纤维结构几乎得以保持。从几丁质/SF共混或混合纳米纤维支架上的细胞相容性和细胞行为来看，含有25%几丁质和75%SF的混合基质以及几丁质/SF共混纳米纤维可能是组织工程支架的潜在候选材料。
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