Spanò Stefania, Galán Jorge E
Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06536, USA.
Curr Opin Microbiol. 2008 Feb;11(1):15-20. doi: 10.1016/j.mib.2007.12.002. Epub 2008 Feb 20.
Fundamental to the biology of many bacterial pathogens are bacterial proteins with the capacity to modulate host cellular functions. These bacterial proteins are delivered to the host's molecular targets by a great diversity of mechanisms of varying complexity. The different delivery mechanisms are adapted to the specific biology of the pathogen. Here we focus our attention on a recently described delivery pathway adapted to the biology of an intracellular pathogen, in which an exotoxin is delivered from an intracellular location to its molecular target through autocrine and paracrine pathways.
许多细菌病原体生物学的基础是具有调节宿主细胞功能能力的细菌蛋白。这些细菌蛋白通过各种各样复杂程度各异的机制被递送到宿主的分子靶点。不同的递送机制适应病原体的特定生物学特性。在这里，我们将注意力集中在一种最近描述的、适应细胞内病原体生物学特性的递送途径上，在这种途径中，一种外毒素通过自分泌和旁分泌途径从细胞内位置被递送到其分子靶点。
