人类巨细胞病毒微小RNA的鉴定与功能
Identification and function of human cytomegalovirus microRNAs.
作者信息
Grey Finn, Nelson Jay
机构信息
Vaccine & Gene Therapy Institute, 505 NW 185th Avenue, Oregon Health Sciences University, Portland, OR 97006, USA.
出版信息
J Clin Virol. 2008 Mar;41(3):186-91. doi: 10.1016/j.jcv.2007.11.024.
Abstract
microRNAs are an extensive class of non-coding genes that regulate gene expression through post-transcriptional repression. These small RNAs are evolutionarily conserved and are likely to be a basic mechanism of gene regulation present within most eukaryotic organisms. Over 100 viral miRNAs have been identified to date through a combination of bioinformatics and cloning studies. In this review we discuss the use of bioinformatics for the identification of HCMV miRNAs and also for the discovery of potential target transcripts. Such studies will enable us to define the functional role of viral miRNAs and gain a better understanding of viral gene regulation.
摘要
微小RNA是一类广泛的非编码基因，通过转录后抑制来调节基因表达。这些小RNA在进化上是保守的，很可能是大多数真核生物中存在的一种基本基因调控机制。通过生物信息学和克隆研究相结合，迄今已鉴定出100多种病毒微小RNA。在本综述中，我们讨论了生物信息学在鉴定人巨细胞病毒微小RNA以及发现潜在靶转录本方面的应用。此类研究将使我们能够确定病毒微小RNA的功能作用，并更好地理解病毒基因调控。
相似文献
1
Identification and function of human cytomegalovirus microRNAs.人类巨细胞病毒微小RNA的鉴定与功能
J Clin Virol. 2008 Mar;41(3):186-91. doi: 10.1016/j.jcv.2007.11.024.
3
Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice.病毒微小RNA对Akt的调控对于人巨细胞病毒在CD34 +造血祖细胞和人源化小鼠中从潜伏状态重新激活是必要的。
PLoS Pathog. 2024 Dec 11;20(12):e1012285. doi: 10.1371/journal.ppat.1012285. eCollection 2024 Dec.
4
N6-methyladenosine modification of HCMV IE1 transcript promotes the repressive state of viral genome to achieve latent infection.人巨细胞病毒IE1转录本的N6-甲基腺苷修饰促进病毒基因组的抑制状态以实现潜伏感染。
Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2508475122. doi: 10.1073/pnas.2508475122. Epub 2025 Jun 10.
6
A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection.一项微小RNA筛选确定Wnt信号通路是黄病毒感染期间干扰素反应的调节因子。
J Virol. 2017 Mar 29;91(8). doi: 10.1128/JVI.02388-16. Print 2017 Apr 15.
7
Third intracellular loop of HCMV US28 is necessary for signaling and viral reactivation.人巨细胞病毒US28的第三个细胞内环对于信号传导和病毒再激活是必需的。
J Virol. 2025 Jan 31;99(1):e0180124. doi: 10.1128/jvi.01801-24. Epub 2024 Dec 10.
8
Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways.人类巨细胞病毒 miR-US5-2 下调 GAB1 通过调节表皮生长因子受体信号通路调节细胞增殖和表达。
mSphere. 2020 Aug 5;5(4):e00582-20. doi: 10.1128/mSphere.00582-20.
9
10
Host signaling and EGR1 transcriptional control of human cytomegalovirus replication and latency.宿主信号和 EGR1 转录对人巨细胞病毒复制和潜伏的控制。
PLoS Pathog. 2019 Nov 14;15(11):e1008037. doi: 10.1371/journal.ppat.1008037. eCollection 2019 Nov.
引用本文的文献
1
Inter-regulatory role of microRNAs in interaction between viruses and stem cells.微小RNA在病毒与干细胞相互作用中的相互调节作用。
World J Stem Cells. 2021 Aug 26;13(8):985-1004. doi: 10.4252/wjsc.v13.i8.985.
2
Regulation of the MIE Locus During HCMV Latency and Reactivation.人巨细胞病毒潜伏和再激活过程中主要立即早期基因座的调控
Pathogens. 2020 Oct 23;9(11):869. doi: 10.3390/pathogens9110869.
3
MicroRNAs of Human Herpesvirus 6A and 6B in Serum and Cerebrospinal Fluid of Multiple Sclerosis Patients.人疱疹病毒 6A 和 6B 在多发性硬化症患者血清和脑脊液中的 microRNAs。
Front Immunol. 2020 Sep 18;11:2142. doi: 10.3389/fimmu.2020.02142. eCollection 2020.
4
Understanding HCMV Latency Using Unbiased Proteomic Analyses.利用无偏蛋白质组学分析理解人巨细胞病毒潜伏感染
Pathogens. 2020 Jul 20;9(7):590. doi: 10.3390/pathogens9070590.
5
The Interplay between Human Cytomegalovirus and Pathogen Recognition Receptor Signaling.人巨细胞病毒与病原体识别受体信号转导的相互作用。
Viruses. 2018 Sep 20;10(10):514. doi: 10.3390/v10100514.
6
Human Cytomegalovirus Encoded miR-US25-1-5p Attenuates CD147/EMMPRIN-Mediated Early Antiviral Response.人巨细胞病毒编码的 miR-US25-1-5p 减弱 CD147/EMMPRIN 介导的早期抗病毒反应。
Viruses. 2017 Dec 1;9(12):365. doi: 10.3390/v9120365.
7
Manipulation of Viral MicroRNAs as a Potential Antiviral Strategy for the Treatment of Cytomegalovirus Infection.操纵病毒微小RNA作为治疗巨细胞病毒感染的潜在抗病毒策略
Viruses. 2017 May 19;9(5):118. doi: 10.3390/v9050118.
8
Cleavage of Dicer protein by I7 protease during vaccinia virus infection.痘苗病毒感染期间I7蛋白酶对Dicer蛋白的切割作用。
PLoS One. 2015 Mar 27;10(3):e0120390. doi: 10.1371/journal.pone.0120390. eCollection 2015.
9
A human herpesvirus 6A-encoded microRNA: role in viral lytic replication.一种人类疱疹病毒6A编码的微小RNA：在病毒裂解复制中的作用。
J Virol. 2015 Mar;89(5):2615-27. doi: 10.1128/JVI.02007-14. Epub 2014 Dec 17.
10
Detection of circulating hcmv-miR-UL112-3p in patients with glioblastoma, rheumatoid arthritis, diabetes mellitus and healthy controls.胶质母细胞瘤、类风湿性关节炎、糖尿病患者及健康对照者循环血中hcmv-miR-UL112-3p的检测
PLoS One. 2014 Dec 2;9(12):e113740. doi: 10.1371/journal.pone.0113740. eCollection 2014.
本文引用的文献
1
A human cytomegalovirus-encoded microRNA regulates expression of multiple viral genes involved in replication.一种人类巨细胞病毒编码的微小RNA可调节多个参与复制的病毒基因的表达。
PLoS Pathog. 2007 Nov;3(11):e163. doi: 10.1371/journal.ppat.0030163.
2
Host immune system gene targeting by a viral miRNA.病毒微小RNA对宿主免疫系统基因的靶向作用。
Science. 2007 Jul 20;317(5836):376-81. doi: 10.1126/science.1140956.
3
Marek's disease virus type 2 (MDV-2)-encoded microRNAs show no sequence conservation with those encoded by MDV-1.2型马立克氏病病毒（MDV-2）编码的微小RNA与MDV-1编码的微小RNA没有序列保守性。
J Virol. 2007 Jul;81(13):7164-70. doi: 10.1128/JVI.00112-07. Epub 2007 Apr 25.
4
The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.人巨细胞病毒复制过程中，60千道尔顿和40千道尔顿的IE2蛋白并非必需，但对于高效的延迟早期和晚期基因表达以及传染性病毒的产生却是必需的。
J Virol. 2007 Mar;81(6):2573-83. doi: 10.1128/JVI.02454-06. Epub 2007 Jan 3.
5
CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation.CD8 T细胞通过对转录激活的表位特异性感知来控制巨细胞病毒的潜伏。
J Virol. 2006 Nov;80(21):10436-56. doi: 10.1128/JVI.01248-06. Epub 2006 Aug 23.
6
Marek's disease virus encodes MicroRNAs that map to meq and the latency-associated transcript.马立克氏病病毒编码的微小RNA定位于meq基因和潜伏相关转录本。
J Virol. 2006 Sep;80(17):8778-86. doi: 10.1128/JVI.00831-06.
7
Anti-apoptotic function of a microRNA encoded by the HSV-1 latency-associated transcript.由单纯疱疹病毒1型潜伏相关转录本编码的一种微小RNA的抗凋亡功能。
Nature. 2006 Jul 6;442(7098):82-5. doi: 10.1038/nature04836. Epub 2006 May 31.
8
Prediction and identification of herpes simplex virus 1-encoded microRNAs.单纯疱疹病毒1型编码的微小RNA的预测与鉴定
J Virol. 2006 Jun;80(11):5499-508. doi: 10.1128/JVI.00200-06.
9
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed.爱泼斯坦-巴尔病毒微小RNA在进化上保守且差异表达。
PLoS Pathog. 2006 Mar;2(3):e23. doi: 10.1371/journal.ppat.0020023. Epub 2006 Mar 24.
10
Sequence-specific interference by small RNAs derived from adenovirus VAI RNA.源自腺病毒VAI RNA的小RNA的序列特异性干扰。
FEBS Lett. 2006 Mar 6;580(6):1553-64. doi: 10.1016/j.febslet.2006.01.085. Epub 2006 Feb 3.
Zotero 插件