van Beers Eduard J, Nieuwdorp Max, Duits Ashley J, Evers Ludo M, Schnog John-John B, Biemond Bart J
Haematologica. 2008 Feb;93(2):307-8. doi: 10.3324/haematol.12027.
The glycocalyx is an important anti-inflammatory and anti-adhesive barrier at the luminal side of endothelial cells. Glycocalyx volume was significantly reduced in sickle cell patients (HbSS/HbSbeta(0)-thalassemia median 0.47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease.
糖萼是内皮细胞腔面重要的抗炎和抗黏附屏障。与对照组（1×10⁹L，四分位距0.52 - 1.77）相比，镰状细胞病患者（HbSS/HbSβ⁰-地中海贫血中位数0.47L，四分位距0.27 - 0.66，HbSC/HbSβ⁺-地中海贫血0.23L，0.0 - 0.58）的糖萼体积显著减少（p = 0.03）。糖萼减少可能是镰状细胞病病理生理学中的一个新因素。
