Gharehbaghi Manizheh M, Peirovifar Ali, Gharehbaghi Parvin M
Department of Neonatology, Tabriz University of Medical Sciences, Tabriz, Iran.
Saudi Med J. 2008 Feb;29(2):224-8.
To compare inflammatory mediators in the cord blood of premature newborn infants with premature rupture of membranes (PROM) and intact membranes.
Eighty-nine premature neonates with gestational age of 27-34 weeks that delivered in Ghaem Hospital in Mashhad, Iran from June 2005 to March 2006 were enrolled in a prospective observational study, and their umbilical cord plasma was collected at birth. They were allocated into 2 groups (45 patients with PROM, and 44 neonates with intact membranes). Interleukin-6 (IL-6) and C-reactive protein (CRP) levels were measured in cord plasma by the enzyme linked immunoassay (ELISA) method.
Mean cord plasma IL-6 levels in preterm neonates with PROM was 205.71 pg/ml, and in neonates with intact membranes was 33.3 pg/ml for IL-6 (p=0.000). The mean cord blood CRP level in newborns with PROM was 10.2 microgram/ml, and in those with intact membranes was 1.6 microgram/ml (p=0.41). Early onset sepsis was more frequent in infants with PROM than premature infants with intact membrane (38% versus 10%, p=0.001). In neonates with PROM, the mean cord blood IL-6 level was significantly higher in septic newborns (414.28 verus 40.44 pg/ml, p=0.000).
The premature newborn infants with PROM had increased IL-6 levels in cord blood, which was significantly higher in neonates that developed early onset sepsis.
比较胎膜早破（PROM）的早产新生儿与胎膜完整的早产新生儿脐带血中的炎症介质。
对2005年6月至2006年3月在伊朗马什哈德的加姆医院分娩的89例孕27 - 34周的早产新生儿进行前瞻性观察研究，并在出生时采集他们的脐带血浆。他们被分为两组（45例胎膜早破患者和44例胎膜完整的新生儿）。采用酶联免疫吸附测定（ELISA）法测定脐带血浆中的白细胞介素-6（IL-6）和C反应蛋白（CRP）水平。
胎膜早破的早产新生儿脐带血浆中IL-6的平均水平为205.71 pg/ml，胎膜完整的新生儿中IL-6为33.3 pg/ml（p = 0.000）。胎膜早破新生儿的脐带血CRP平均水平为10.2微克/毫升，胎膜完整的新生儿为1.6微克/毫升（p = 0.41）。胎膜早破的婴儿比胎膜完整的早产儿早发性败血症更常见（38%对10%，p = 0.001）。在胎膜早破的新生儿中，败血症新生儿的脐带血IL-6平均水平显著更高（414.28对40.44 pg/ml，p = 0.000）。
胎膜早破的早产新生儿脐带血中IL-6水平升高，在发生早发性败血症的新生儿中显著更高。
