Strom Sara S, Yamamura Yuko, Flores-Sandoval F Nery, Pettaway Curtis A, Lopez David S
The University of Texas M.D. Anderson Cancer Center, Department of Epidemiology, Houston, Texas, USA.
Prostate. 2008 Apr 1;68(5):563-70. doi: 10.1002/pros.20713.
There is a paucity of information regarding prostate cancer (PCa) risk factors among Hispanics, the fastest-growing ethnic group in the United States.
This population-based case-control study included 176 Texas men of Mexican descent with PCa and 174 age- and ethnicity-matched controls. Demographic, lifetime occupational history, family history of cancer, lifestyle (e.g., smoking, alcohol, diet, and recreational physical activity) and anthropometric information were collected by personal interviews. Chemical exposure and physical activity were determined using job-exposure matrices for each reported job.
Logistic regression models adjusted for relevant covariates were used to evaluate their independent effects. Compared to controls, cases were three times more likely to work in jobs with high agrichemical exposure (OR = 3.44, 95% CI 1.84-6.44), and 54% less likely to work in jobs with moderate/high occupational physical activity (OR = 0.46, 95% CI 0.28-0.77). In analyses stratified by stage, cases with organ-confined PCa were three times more likely to have high agrichemical exposure (OR = 3.39, 9%CI 1.68-6.84), and 56% less likely to have moderate/high levels of occupational physical activity (OR = 0.44, 95% CI 0.26-0.76). Increased risk of being diagnosed with advanced PCa was associated with obesity at time of diagnosis (OR = 2.50, 95% CI 1.20-5.20) and high levels of agrichemical exposure (OR = 4.65, 95% CI 1.97-10.97), but not with occupational physical activity.
This case-control study, the first conducted in a homogeneous Hispanic population, identified modifiable PCa risk factors, such as physical activity and agrichemical exposure, which may be useful in developing interventions for this understudied population.
在美国增长最快的族裔群体西班牙裔中，关于前列腺癌（PCa）风险因素的信息匮乏。
这项基于人群的病例对照研究纳入了176名患有PCa的德克萨斯州墨西哥裔男性以及174名年龄和种族匹配的对照。通过个人访谈收集人口统计学、终生职业史、癌症家族史、生活方式（如吸烟、饮酒、饮食和休闲体育活动）以及人体测量信息。使用针对每份报告工作的职业暴露矩阵来确定化学物质暴露和体育活动情况。
使用针对相关协变量进行调整的逻辑回归模型来评估其独立影响。与对照组相比，病例从事高农业化学物质暴露工作的可能性是对照组的三倍（比值比[OR]=3.44，95%置信区间[CI]为1.84 - 6.44），而从事中度/高度职业体育活动工作的可能性比对照组低54%（OR = 0.46，95% CI为0.28 - 0.77）。在按阶段分层的分析中，局限于器官的PCa病例有高农业化学物质暴露的可能性是对照组的三倍（OR = 3.39，9% CI为1.68 - 6.84），而有中度/高度职业体育活动水平的可能性比对照组低56%（OR = 0.44，95% CI为0.26 - 0.76）。被诊断为晚期PCa的风险增加与诊断时的肥胖（OR = 2.50，95% CI为1.20 - 5.20）以及高农业化学物质暴露水平（OR = 4.65，95% CI为1.97 - 10.97）相关，但与职业体育活动无关。
这项病例对照研究是首次在同质化的西班牙裔人群中开展，确定了可改变的PCa风险因素，如体育活动和农业化学物质暴露，这可能有助于为这个研究不足的人群制定干预措施。
