非洲裔男性前列腺癌发病率、侵袭性和死亡率的全球模式。
Global patterns of prostate cancer incidence, aggressiveness, and mortality in men of african descent.
作者信息
Rebbeck Timothy R, Devesa Susan S, Chang Bao-Li, Bunker Clareann H, Cheng Iona, Cooney Kathleen, Eeles Rosalind, Fernandez Pedro, Giri Veda N, Gueye Serigne M, Haiman Christopher A, Henderson Brian E, Heyns Chris F, Hu Jennifer J, Ingles Sue Ann, Isaacs William, Jalloh Mohamed, John Esther M, Kibel Adam S, Kidd Lacreis R, Layne Penelope, Leach Robin J, Neslund-Dudas Christine, Okobia Michael N, Ostrander Elaine A, Park Jong Y, Patrick Alan L, Phelan Catherine M, Ragin Camille, Roberts Robin A, Rybicki Benjamin A, Stanford Janet L, Strom Sara, Thompson Ian M, Witte John, Xu Jianfeng, Yeboah Edward, Hsing Ann W, Zeigler-Johnson Charnita M
机构信息
Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, 217 Blockley Hall, 423 Guardian Drive, Philadelphia, PA 19104, USA ; Abramson Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Prostate Cancer. 2013;2013:560857. doi: 10.1155/2013/560857. Epub 2013 Feb 13.
Prostate cancer (CaP) is the leading cancer among men of African descent in the USA, Caribbean, and Sub-Saharan Africa (SSA). The estimated number of CaP deaths in SSA during 2008 was more than five times that among African Americans and is expected to double in Africa by 2030. We summarize publicly available CaP data and collected data from the men of African descent and Carcinoma of the Prostate (MADCaP) Consortium and the African Caribbean Cancer Consortium (AC3) to evaluate CaP incidence and mortality in men of African descent worldwide. CaP incidence and mortality are highest in men of African descent in the USA and the Caribbean. Tumor stage and grade were highest in SSA. We report a higher proportion of T1 stage prostate tumors in countries with greater percent gross domestic product spent on health care and physicians per 100,000 persons. We also observed that regions with a higher proportion of advanced tumors reported lower mortality rates. This finding suggests that CaP is underdiagnosed and/or underreported in SSA men. Nonetheless, CaP incidence and mortality represent a significant public health problem in men of African descent around the world.
前列腺癌（CaP）是美国、加勒比地区和撒哈拉以南非洲（SSA）非洲裔男性中最常见的癌症。2008年SSA地区CaP死亡估计人数超过非裔美国人的五倍，预计到2030年非洲地区这一数字将翻倍。我们汇总了公开可得的CaP数据，并收集了来自非洲裔男性与前列腺癌（MADCaP）联盟以及非洲加勒比癌症联盟（AC3）的数据，以评估全球非洲裔男性中的CaP发病率和死亡率。美国和加勒比地区非洲裔男性的CaP发病率和死亡率最高。SSA地区的肿瘤分期和分级最高。我们报告称，在医疗保健支出占国内生产总值比例更高且每10万人中医生数量更多的国家，T1期前列腺肿瘤的比例更高。我们还观察到，晚期肿瘤比例较高的地区报告的死亡率较低。这一发现表明，SSA地区男性的CaP存在诊断不足和/或报告不足的情况。尽管如此，CaP发病率和死亡率仍是全球非洲裔男性中一个重大的公共卫生问题。
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