钯催化邻碘苯胺与亚胺酰氯进行环羰基化反应以制备喹唑啉-4(3H)-酮。

Palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides to produce quinazolin-4(3H)-ones.

作者信息

Zheng Zhaoyan, Alper Howard

机构信息

Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.

出版信息

Org Lett. 2008 Mar 6;10(5):829-32. doi: 10.1021/ol7029454. Epub 2008 Feb 5.

DOI:10.1021/ol7029454

PMID:18247629

Abstract

A wide variety of substituted quinazolin-4(3H)-ones were prepared in 63-91% yields by the palladium-catalyzed cyclocarbonylation of o-iodoanilines with imidoyl chlorides and carbon monoxide. The reaction is believed to proceed via in situ formation of an amidine, followed by oxidative addition, CO insertion, and intramolecular cyclization to give the substituted quinazolin-4(3H)-ones.

摘要

通过钯催化邻碘苯胺与亚胺酰氯和一氧化碳的环羰基化反应，以63% - 91%的产率制备了多种取代喹唑啉-4(3H)-酮。据信该反应通过原位形成脒，然后进行氧化加成、CO插入和分子内环化，从而得到取代喹唑啉-4(3H)-酮。