钯催化（2-碘芳基）丙二酸二乙酯与亚胺酰氯的羰基化-脱羧反应：合成取代异喹啉-1(2H)-酮的有效途径

Palladium-catalyzed carbonylation-decarboxylation of diethyl(2-iodoaryl)malonates with imidoyl chlorides: an efficient route to substituted isoquinolin-1(2H)-ones.

作者信息

Zheng Zhaoyan, Alper Howard

机构信息

Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.

出版信息

Org Lett. 2008 Nov 6;10(21):4903-6. doi: 10.1021/ol801991m. Epub 2008 Oct 9.

DOI:10.1021/ol801991m

PMID:18842052

Abstract

A wide variety of substituted isoquinolin-1(2H)-ones were synthesized in reasonable to good yields by the palladium-catalyzed cyclization of diethyl(2-iodoaryl)malonates with imidoyl chlorides and carbon monoxide in tetrahydrofuran. A palladium-catalyzed carbonylation-decarboxylation process may be involved in the one-step synthesis of the isoquinolin-1(2H)-ones.

摘要

通过钯催化的（2-碘芳基）丙二酸二乙酯与亚胺酰氯和一氧化碳在四氢呋喃中进行环化反应，以合理至良好的产率合成了多种取代异喹啉-1(2H)-酮。异喹啉-1(2H)-酮的一步合成可能涉及钯催化的羰基化-脱羧过程。