• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.

作者信息

Doxey J C, Smith C F, Walker J M

出版信息

Br J Pharmacol. 1977 May;60(1):91-6. doi: 10.1111/j.1476-5381.1977.tb16752.x.

DOI:10.1111/j.1476-5381.1977.tb16752.x
PMID:18248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1667189/
Abstract
  1. Low frequency (0.1 Hz) electrical stimulation of the rat isolated vas deferens produced regular contractions that were inhibited by low concentrations of clonidine. 2. The inhibition of the vas deferens produced by clonidine was presynaptic in origin and involved alpha-adrenoceptors. 3. Presynaptic alpha-adrenoceptor antagonist activity was assessed by studying the effects of increasing concentrations of the antagonists on cumulative clonidine dose-response curves on the stimulated vas deferens. 4. Postsynaptic alpha-adrenoceptor antagonist activity was assessed by comparison of control cumulative noradrenaline dose-response curves with those in the presence of increasing concentrations of antagonists in the rat anococcygeus muscle. 5. The results indicate that yohimbine and phentolamine are more potent in blocking presynaptic than postsynaptic alpha-adrenoceptors. Phenoxybenzamine and prazosin block postsynaptic alpha-adrenoceptors preferentially. 6. The findings support the view that presynaptic and postsynaptic alpha-adrenoceptors differ in their sensitivity to alpha-adrenoceptor antagonists.
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/7d4a1e002da7/brjpharm00444-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/cb1b4f4ad573/brjpharm00444-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/4feb4835c9ad/brjpharm00444-0094-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/7d4a1e002da7/brjpharm00444-0095-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/cb1b4f4ad573/brjpharm00444-0094-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/4feb4835c9ad/brjpharm00444-0094-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0847/1667189/7d4a1e002da7/brjpharm00444-0095-a.jpg

相似文献

1
Selectivity of blocking agents for pre-and postsynaptic alpha-adrenoceptors.
Br J Pharmacol. 1977 May;60(1):91-6. doi: 10.1111/j.1476-5381.1977.tb16752.x.
2
[Comparative study of the pre and post-synaptic alpha blocking activity of thymoxamine and its metabolites in the rat vas deferens (author's transl)].胸腺氧胺及其代谢产物在大鼠输精管中突触前和突触后α阻断活性的比较研究（作者译）
J Pharmacol. 1981 Jan-Mar;12(1):15-25.
3
Pre- and postsynaptic alpha-adrenoceptor blocking activity of raubasine in the rat vas deferens.萝巴新在大鼠输精管中的突触前和突触后α-肾上腺素能受体阻断活性。
Br J Pharmacol. 1981 Dec;74(4):739-45. doi: 10.1111/j.1476-5381.1981.tb10706.x.
4
Effects of alpha-adrenoceptor agonists and antagonists and of antidepressant drugs on pre- and postsynaptic alpha-adrenoceptors.α-肾上腺素能受体激动剂、拮抗剂及抗抑郁药对突触前和突触后α-肾上腺素能受体的作用。
Eur J Pharmacol. 1980 Oct 3;67(1):33-40. doi: 10.1016/0014-2999(80)90005-9.
5
Comparison of pre- and postsynaptic alpha-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat.E-643对大鼠离体输精管突触前和突触后α-肾上腺素能受体阻断作用的比较。
Jpn J Pharmacol. 1981 Jun;31(3):361-8. doi: 10.1254/jjp.31.361.
6
Studies on RX 781094: a selective, potent and specific antagonist of alpha 2-adrenoceptors.RX 781094的研究：一种α2肾上腺素能受体的选择性、强效且特异性拮抗剂。
Br J Pharmacol. 1983 Mar;78(3):489-505. doi: 10.1111/j.1476-5381.1983.tb08809.x.
7
Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens.萝巴新立体异构体对大鼠输精管突触前和突触后α-肾上腺素能受体的影响。
Br J Pharmacol. 1984 Oct;83(2):505-10. doi: 10.1111/j.1476-5381.1984.tb16514.x.
8
Effects of prazosin and phentolamine on responses to field stimulation and to noradrenaline in vas deferens and anococcygeus muscle of the rat.哌唑嗪和酚妥拉明对大鼠输精管和肛尾肌对场刺激及去甲肾上腺素反应的影响。
Arch Int Pharmacodyn Ther. 1978 Jun;233(2):209-20.
9
Pharmacological analysis of the postjunctional alpha-adrenoceptors of the rat anococcygeus muscle and vas deferens.大鼠肛门尾骨肌和输精管后接头α-肾上腺素能受体的药理学分析。
Arch Int Pharmacodyn Ther. 1985 Jul;276(1):106-11.
10
[Action of dihydroergocristine at pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens].[二氢麦角隐亭对大鼠离体输精管突触前和突触后α-肾上腺素能受体的作用]
J Pharmacol. 1983 Apr-Jun;14(2):151-9.

引用本文的文献

1
Neurochemical and Cardiovascular Effects of 4-Chloro Ring-Substituted Synthetic Cathinones in Rats.4-氯环取代合成卡西酮对大鼠的神经化学和心血管效应。
J Pharmacol Exp Ther. 2023 Jun;385(3):162-170. doi: 10.1124/jpet.122.001478. Epub 2023 Jan 20.
2
Morroniside, a secoiridoid glycoside from Cornus officinalis, attenuates neuropathic pain by activation of spinal glucagon-like peptide-1 receptors.山茱萸苷是山茱萸中的一种裂环环烯醚萜苷，它通过激活脊髓胰高血糖素样肽-1受体来减轻神经性疼痛。
Br J Pharmacol. 2017 Apr;174(7):580-590. doi: 10.1111/bph.13720. Epub 2017 Feb 16.
3
Effect of fractionated extracts and isolated pure compounds of Spondias mombin (L. Anacardiaceae) leaves on novelty-induced rearing and grooming behaviours in mice.

本文引用的文献

1
Cumulative dose-response curves. II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters.累积剂量-反应曲线。II. 离体器官中剂量-反应曲线的制作技术及药物参数的评估
Arch Int Pharmacodyn Ther. 1963;143:299-330.
2
Dual site of action of phenoxybenzamine in the cat's spleen; blockade of alpha-adrenergic receptors and inhibition of re-uptake of neurally released norepinephrine.酚苄明在猫脾脏中的双重作用位点；α-肾上腺素能受体阻断和对神经释放去甲肾上腺素再摄取的抑制。
Experientia. 1964 May 15;20(5):272-3. doi: 10.1007/BF02151802.
3
The rat anococcygeus; a new, densely innervated smooth muscle preparation.
芒果（漆树科）叶的分级提取物和分离出的纯化合物对小鼠新奇诱导的竖毛和理毛行为的影响。
Afr J Tradit Complement Altern Med. 2013 Aug 12;10(5):244-55. doi: 10.4314/ajtcam.v10i5.5. eCollection 2013.
4
The effect of intrathecal mu, delta, kappa, and alpha-2 agonists on thermal hyperalgesia induced by mild burn on hind paw in rats.鞘内给予 μ、δ、κ 和 α-2 激动剂对大鼠后足底轻度烧伤诱导的热痛觉过敏的影响。
J Anesth. 2011 Dec;25(6):884-91. doi: 10.1007/s00540-011-1240-2. Epub 2011 Oct 9.
5
Post-junctional alpha-adrenoceptors and basal limb vascular tone in healthy men.健康男性的节后α-肾上腺素能受体与基础肢体血管张力
J Physiol. 2002 May 1;540(Pt 3):1103-10. doi: 10.1113/jphysiol.2001.015297.
6
Reductions in basal limb blood flow and vascular conductance with human ageing: role for augmented alpha-adrenergic vasoconstriction.随着人类衰老，基础肢体血流量和血管传导性降低：α-肾上腺素能血管收缩增强的作用。
J Physiol. 2001 Nov 1;536(Pt 3):977-83. doi: 10.1111/j.1469-7793.2001.00977.x.
7
Study of the mechanism of the relaxant action of (+)-glaucine in rat vas deferens.（+）-青藤碱对大鼠输精管舒张作用机制的研究。
Br J Pharmacol. 1993 Nov;110(3):943-8. doi: 10.1111/j.1476-5381.1993.tb13904.x.
8
Effect of adrenoceptor agonists on striated muscle strips of the canine oesophagus.肾上腺素能受体激动剂对犬食管横纹肌条的作用。
Br J Pharmacol. 1993 Sep;110(1):297-302. doi: 10.1111/j.1476-5381.1993.tb13808.x.
9
Effect of the vascular endothelium on noradrenaline-induced contractions in non-pregnant and pregnant guinea-pig uterine arteries.血管内皮对未孕和孕豚鼠子宫动脉中去甲肾上腺素诱导收缩的影响。
Br J Pharmacol. 1995 Feb;114(4):805-15. doi: 10.1111/j.1476-5381.1995.tb13276.x.
10
The distribution of adrenoceptors and other drug receptors between the two ends of the rat vas deferens as revealed by selective agonists and antagonists.选择性激动剂和拮抗剂揭示大鼠输精管两端肾上腺素能受体及其他药物受体的分布情况。
Br J Pharmacol. 1980;71(2):445-58. doi: 10.1111/j.1476-5381.1980.tb10957.x.
大鼠肛门尾骨肌；一种新的、神经支配密集的平滑肌标本。
Br J Pharmacol. 1971 Oct;43(2):430P.
4
Presynaptic regulation of catecholamine release.儿茶酚胺释放的突触前调节。
Biochem Pharmacol. 1974 Jul 1;23(13):1793-800. doi: 10.1016/0006-2952(74)90187-7.
5
Alpha sympathomimetic inhibition of adrenergic and cholinergic transmission in the rabbit heart.α拟交感神经药对兔心脏肾上腺素能和胆碱能传递的抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(1):18-45. doi: 10.1007/BF00501004.
6
Evidence against adrenergic motor transmission in the guinea-pig vas deferens.豚鼠输精管中肾上腺素能运动传递的反证。
J Physiol. 1971 Jul;216(2):359-89. doi: 10.1113/jphysiol.1971.sp009530.
7
Negative feed-back regulation of noradrenaline release by nerve stimulation in the perfused cat's spleen: differences in potency of phenoxybenzamine in blocking the pre- and post-synaptic adrenergic receptors.灌注猫脾脏中神经刺激对去甲肾上腺素释放的负反馈调节：酚苄明阻断突触前和突触后肾上腺素能受体的效力差异。
J Physiol. 1974 Mar;237(3):505-19. doi: 10.1113/jphysiol.1974.sp010495.
8
Comparison of the effects of clonidine on pre- and postsynaptic adrenoceptors in the rabbit pulmonary artery. Alpha-sympathomimetic inhibition of Neurogenic vasoconstriction.可乐定对兔肺动脉突触前和突触后肾上腺素能受体作用的比较。神经源性血管收缩的α-拟交感神经抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1974;285(2):133-50. doi: 10.1007/BF00501149.
9
Cardiovascular effects of prazosin in normotensive and genetically hypertensive rats.哌唑嗪对正常血压和遗传性高血压大鼠的心血管效应。
Clin Exp Pharmacol Physiol. 1975 Jul-Aug;2(4):297-304. doi: 10.1111/j.1440-1681.1975.tb01836.x.
10
Pre- and postsynaptic components in effect of drugs with alpha adrenoceptor affinity.具有α肾上腺素能受体亲和力的药物作用中的突触前和突触后成分。
Nature. 1975 Apr 3;254(5499):440-1. doi: 10.1038/254440a0.