Ciesek Sandra, Helfritz Fabian A, Lehmann Ulrich, Becker Thomas, Strassburg Christian P, Neipp Michael, Ciner Ayse, Fytili Paraskevi, Tillmann Hans L, Manns Michael Peter, Wedemeyer Heiner
Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School, Hannover, Germany.
J Infect Dis. 2008 Feb 1;197(3):355-60. doi: 10.1086/525286.
Occult hepatitis B is defined as the persistence of hepatitis B virus (HBV) DNA in persons without HBV surface antigen (HBsAg). The primary site for HBV persistence in persons with occult hepatitis B is considered to be the liver. We provide virological and immunological evidence for long-term persistence of HBV, even after removal of the infected liver, in 25 consecutive, randomly selected liver transplant recipients who tested positive for anti-HBV core antigen (anti-HBcAg) and negative for HBsAg at the time of transplantation. Furthermore, in a cohort of 101 anti-HBcAg-positive/HBsAg-negative patients, 2 showed clinical HBV reactivation after transplantation. Thus, these data indicate that a long-term extrahepatic HBV reservoir exists, which is relevant not only for liver transplantation but also for other types of transplantations, including bone marrow grafting.
隐匿性乙型肝炎被定义为在无乙型肝炎病毒（HBV）表面抗原（HBsAg）的人群中HBV DNA持续存在。隐匿性乙型肝炎患者中HBV持续存在的主要部位被认为是肝脏。我们为25例连续、随机选取的肝移植受者提供了病毒学和免疫学证据，证明即使在切除受感染肝脏后，HBV仍能长期持续存在，这些受者在移植时抗-HBV核心抗原（抗-HBcAg）检测呈阳性而HBsAg检测呈阴性。此外，在一组101例抗-HBcAg阳性/HBsAg阴性患者中，有2例在移植后出现临床HBV再激活。因此，这些数据表明存在一个长期的肝外HBV储存库，这不仅与肝移植有关，也与包括骨髓移植在内的其他类型移植有关。
