Alavian Seyed Moayed, Miri Seyed Mohammad, Hollinger F Blaine, Jazayeri Seyed Mohammad
Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Hepat Mon. 2012 Aug;12(8):e6126. doi: 10.5812/hepatmon.6126. Epub 2012 Aug 25.
Occult hepatitis B (OHB), or persistent HBV DNA in patients who are hepatitis B surface antigen (HBsAg) negative, is a recently recognized entity. In an attempt to summarize the issues, this review presents an overview of the current proposed hypothesis on the clinical relevance and also updates the knowledge on the classification of OHB in different clinical settings.
OHB COULD BE FOUND IN DIFFERENT POPULATION AND CLINICAL BACKGROUNDS INCLUDING: viral co-infections (with either human immunodeficiency or hepatitis C viruses), HBV chronic carriers, dialysis patients, transplantation settings and certain clinical situations (named in here: special clinical settings) with no apparent distinguishable clinical parameters.
The exact magnitude, pathogenesis, and clinical relevance of OHB are unclear. Even the possible role exerted by this cryptic infection on liver disease outcome, and hepatocellular carcinoma development remains unknown.
Monitoring of Individuals with positive anti-HBc, mass immunization programs and improvement in diagnostic tools seem to be important to control the probability of transmission of HBV through cryptic HBV infection.
隐匿性乙型肝炎（OHB），即乙肝表面抗原（HBsAg）阴性患者体内持续存在乙肝病毒脱氧核糖核酸（HBV DNA），是一种最近才被认识的疾病实体。为了总结相关问题，本综述概述了当前关于其临床相关性的假说，并更新了不同临床环境下隐匿性乙型肝炎分类的知识。
隐匿性乙型肝炎可在不同人群和临床背景中发现，包括：病毒合并感染（人类免疫缺陷病毒或丙型肝炎病毒）、乙肝慢性携带者、透析患者、移植环境以及某些无明显可区分临床参数的临床情况（此处称为：特殊临床环境）。
隐匿性乙型肝炎的确切程度、发病机制和临床相关性尚不清楚。甚至这种隐匿性感染对肝病结局和肝细胞癌发生可能产生的作用也仍然未知。
监测抗-HBc阳性个体、大规模免疫计划以及改进诊断工具对于控制通过隐匿性乙肝病毒感染传播乙肝病毒的可能性似乎很重要。
