Tsuji Brian T, Leonard Steven N, Rhomberg Paul R, Jones Ronald N, Rybak Michael J
Anti-Infective Research Laboratory, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
Diagn Microbiol Infect Dis. 2008 Apr;60(4):441-4. doi: 10.1016/j.diagmicrobio.2007.11.011. Epub 2008 Jan 14.
We evaluated the calculated protein binding based on arithmetic means of MIC values in the presence and absence of protein for daptomycin, telavancin, vancomycin, and teicoplanin against 5 Staphylococcus aureus isolates. The extent of protein binding was lower than expected, particularly for daptomycin and telavancin. These drugs may be more active than predicted based on unbound drug concentrations alone.
我们针对5株金黄色葡萄球菌分离株，评估了达托霉素、替考拉宁、万古霉素和替考拉宁在有蛋白和无蛋白存在情况下基于MIC值算术平均值计算出的蛋白结合情况。蛋白结合程度低于预期，尤其是达托霉素和替考拉宁。这些药物可能比仅基于游离药物浓度预测的更具活性。
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