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高渗盐水对铜绿假单胞菌运动性的抑制作用。

Inhibitory effects of hypertonic saline on P. aeruginosa motility.

作者信息

Havasi Viktória, Hurst Casey O, Briles Travis C, Yang Fan, Bains David G, Hassett Daniel J, Sorscher Eric

机构信息

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.

Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Boulevard, Birmingham, AL 35294-0005, United States.

出版信息

J Cyst Fibros. 2008 Jul;7(4):267-269. doi: 10.1016/j.jcf.2007.11.009. Epub 2008 Jan 31.

DOI:10.1016/j.jcf.2007.11.009
PMID:18249160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2553522/
Abstract

Salt transport defects in CF lungs predispose to overwhelming and fatal respiratory infection caused by Pseudomonas aeruginosa. Motility of this organism is central to pathogenesis in a number of settings. Incubation of numerous strains of P. aeruginosa with hypertonic saline caused a concentration-dependent decrease in bacterial motility. Reduction of P. aeruginosa virulence through this effect may contribute to clinical efficacy of hypertonic saline aerosols in CF patients.

摘要

囊性纤维化（CF）患者肺部的盐转运缺陷易引发由铜绿假单胞菌导致的严重且致命的呼吸道感染。在多种情况下，该细菌的运动性对于发病机制至关重要。将众多铜绿假单胞菌菌株与高渗盐水一起培养会导致细菌运动性呈浓度依赖性降低。通过这种作用降低铜绿假单胞菌的毒力可能有助于高渗盐雾气溶胶对CF患者的临床疗效。

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本文引用的文献

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Mucus clearance and lung function in cystic fibrosis with hypertonic saline.高渗盐水用于囊性纤维化患者的黏液清除与肺功能研究
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A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis.一项针对囊性纤维化患者长期吸入高渗盐水的对照试验。
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FlhA, a component of the flagellum assembly apparatus of Pseudomonas aeruginosa, plays a role in internalization by corneal epithelial cells.鞭毛蛋白A是铜绿假单胞菌鞭毛组装装置的一个组成部分，在角膜上皮细胞的内化过程中发挥作用。
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Inorganic polyphosphate is needed for swimming, swarming, and twitching motilities of Pseudomonas aeruginosa.铜绿假单胞菌的游动、群体迁移和颤动运动需要无机多聚磷酸盐。
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Inorganic polyphosphate is required for motility of bacterial pathogens.无机多聚磷酸盐是细菌病原体运动所必需的。
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