选择性胰岛素抵抗与全身性胰岛素抵抗：一个致病的悖论。
Selective versus total insulin resistance: a pathogenic paradox.
作者信息
Brown Michael S, Goldstein Joseph L
机构信息
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
出版信息
Cell Metab. 2008 Feb;7(2):95-6. doi: 10.1016/j.cmet.2007.12.009.
Mice with type 2 diabetes manifest selective hepatic insulin resistance: insulin fails to suppress gluconeogenesis but continues to activate lipogenesis, producing the deadly combination of hyperglycemia and hypertriglyceridemia. In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance.
2型糖尿病小鼠表现出选择性肝脏胰岛素抵抗：胰岛素无法抑制糖异生，但仍能激活脂肪生成，从而产生高血糖和高甘油三酯血症这一致命组合。在本期《细胞代谢》中，比丁格等人（2008年）表明，完全肝脏胰岛素抵抗的小鼠表现出高血糖但无高甘油三酯血症——这一状态反常地不如选择性胰岛素抵抗严重。
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