Jacobsson Josefin A, Danielsson Pernilla, Svensson Victoria, Klovins Janis, Gyllensten Ulf, Marcus Claude, Schiöth Helgi B, Fredriksson Robert
Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden.
Biochem Biophys Res Commun. 2008 Apr 11;368(3):476-82. doi: 10.1016/j.bbrc.2008.01.087. Epub 2008 Feb 4.
Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P=0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children.
近期研究表明，FTO基因中的单核苷酸多态性（SNPs）易导致儿童期及成年期肥胖。在本研究中，我们检测了FTO基因变异与KIAA1005基因（该基因与FTO基因紧密连锁）变异之间的关联，以及450名特征明确的重度肥胖儿童和512名正常体重对照者中肥胖及肥胖相关特征的情况。FTO基因与多种肥胖相关特征显著相关，而KIAA1005基因中的SNPs则无此关联。按性别分层时，FTO基因变异rs9939609在女孩中与肥胖及体重指数（BMI）相关（P值分别为0.006和0.004），但在男孩中无此关联。在FTO基因rs9939609与肥胖相关特征（如胰岛素敏感性和血糖）的关联中也发现了性别差异。本研究提示，FTO基因可能在儿童严重肥胖及胰岛素抵抗的性别特异性发展中起重要作用。
