中国北京儿童和青少年中，肥胖相关基因的常见 rs9939609 变异与肥胖风险相关。
The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China.
机构信息
Department of Epidemiology, Capital Institute of Pediatrics, 2 Ya Bao Road, 100020 Beijing China.
出版信息
BMC Med Genet. 2010 Jul 5;11:107. doi: 10.1186/1471-2350-11-107.
BACKGROUND
Previous genome-wide association studies for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults. A significant association of the same risk allele has been described in Asian adult populations, but the results are conflicting. In addition, no replication studies have been conducted in children and adolescents of Asian ancestry.
METHODS
A population-based survey was carried out among 3503 children and adolescents (6-18 years of age) in Beijing, China, including 1229 obese and 2274 non-obese subjects. We investigated the association of rs9939609 with BMI and the risk of obesity. In addition, we tested the association of rs9939609 with weight, height, waist circumference, waist-to-height ratio, fat mass percentage, birth weight, blood pressure and related metabolic traits.
RESULTS
We found significant associations of rs9939609 variant with weight, BMI, BMI standard deviation score (BMI-SDS), waist circumference, waist-to-height ratio, and fat mass percentage in children and adolescents (p for trend = 3.29 x 10-5, 1.39 x 10-6, 3.76 x 10-6, 2.26 x 10-5, 1.94 x 10-5, and 9.75 x 10-5, respectively). No significant associations were detected with height, birth weight, systolic and diastolic blood pressure and related metabolic traits such as total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and fasting plasma glucose (all p > 0.05). Each additional copy of the rs9939609 A allele was associated with a BMI increase of 0.79 [95% Confidence interval (CI) 0.47 to 1.10] kg/m2, equivalent to 0.25 (95%CI 0.14 to 0.35) BMI-SDS units. This rs9939609 variant is significantly associated with the risk of obesity under an additive model [Odds ratio (OR) = 1.29, 95% CI 1.11 to 1.50] after adjusting for age and gender. Moreover, an interaction between the FTO rs9939609 genotype and physical activity (p < 0.001) was detected on BMI levels, the effect of rs9939609-A allele on BMI being (0.95 +/- 0.10), (0.77 +/- 0.08) and (0.67 +/- 0.05) kg/m2, for subjects who performed low, moderate and severe intensity physical activity.
CONCLUSION
The FTO rs9939609 variant is strongly associated with BMI and the risk of obesity in a population of children and adolescents in Beijing, China.
背景
先前的全基因组关联研究表明，2 型糖尿病易感性基因中的常见变体 rs9939609 与欧洲儿童和成人的体重指数（BMI）相关。在亚洲成年人群体中也描述了相同风险等位基因的显著关联，但结果存在争议。此外，在亚洲血统的儿童和青少年中没有进行复制研究。
方法
在中国北京对 3503 名儿童和青少年（6-18 岁）进行了一项基于人群的调查，包括 1229 名肥胖者和 2274 名非肥胖者。我们研究了 rs9939609 与 BMI 和肥胖风险的关联。此外，我们还测试了 rs9939609 与体重、身高、腰围、腰高比、体脂百分比、出生体重、血压和相关代谢特征的关联。
结果
我们发现 rs9939609 变体与儿童和青少年的体重、BMI、BMI 标准差评分（BMI-SDS）、腰围、腰高比和体脂百分比显著相关（趋势 p 值分别为 3.29×10-5、1.39×10-6、3.76×10-6、2.26×10-5、1.94×10-5 和 9.75×10-5）。身高、出生体重、收缩压和舒张压以及总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和空腹血糖等相关代谢特征之间未检测到显著相关性（均 p>0.05）。每个 rs9939609 A 等位基因的额外拷贝与 BMI 增加 0.79[95%置信区间（CI）0.47 至 1.10]kg/m2 相关，相当于 0.25（95%CI 0.14 至 0.35）BMI-SDS 单位。该 rs9939609 变体在调整年龄和性别后，在加性模型下与肥胖风险显著相关[优势比（OR）=1.29，95%置信区间（CI）1.11 至 1.50]。此外，还检测到 FTO rs9939609 基因型与体力活动之间的交互作用（p<0.001）对 BMI 水平的影响，rs9939609-A 等位基因对 BMI 的影响分别为 0.95±0.10、0.77±0.08 和 0.67±0.05）kg/m2，适用于进行低、中、高强度体力活动的受试者。
结论
FTO rs9939609 变体与北京儿童和青少年的 BMI 及其肥胖风险密切相关。
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