Ayhan Ali, Gultekin Murat, Dursun Polat, Dogan Nasuh Utku, Aksan Guldeniz, Guven Suleyman, Velipasaoglu Melih, Yuce Kunter
Baskent University Faculty of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Sihhiye, Ankara, Turkey.
Gynecol Oncol. 2008 Feb;108(2):428-32. doi: 10.1016/j.ygyno.2007.09.014.
To analyze the clinicopathological correlations of metastatic lymph node (LN) numbers in patients with epithelial ovarian carcinoma.
A total of 328 patients with epithelial ovarian carcinoma diagnosed and treated at Hacettepe University Hospital during 1982-2005 were retrospectively reviewed. Patients' age, number of resected lymph nodes, clinical disease stage, preoperative Ca-125 levels, peritoneal cytology, presence of ascites, tumor histology, tumor grade, maximal tumor diameter, cytoreductive success, overall and disease-free survivals were compared with respect to the number of metastatic lymph nodes (< 4 vs. > or = 4).
The mean number of resected lymph nodes was 24.5 and mean number of metastatic lymph nodes was 6.2. About 47.3% (n=155) of the patients had < 4 metastatic lymph nodes and the remaining 52.7% of patients (n=173) had > or = 4 metastatic lymph nodes. Univariate comparison of the two groups relived preoperative Ca-125 values, peritoneal cytology and clinical disease stage to be significantly different among the two groups. However, multivariate analysis revealed a high Ca-125 level (> or = 500 IU/l) to be unique factor significantly different among the groups. Survival analysis also could not find a significant difference with respect to overall and disease-free survival among the groups.
The number of metastatic lymph nodes increases as the preoperative Ca-125 values increase. Other patient characteristics do not have a significant effect on the number of metastatic lymph nodes. Metastatic LN number does not have a prognostic significance in terms of either the overall or the disease-free survival. Prospective series are needed for a definitive conclusion.
分析上皮性卵巢癌患者转移性淋巴结（LN）数量与临床病理特征的相关性。
回顾性分析1982年至2005年在哈杰泰佩大学医院诊断并接受治疗的328例上皮性卵巢癌患者。比较患者年龄、切除淋巴结数量、临床疾病分期、术前Ca-125水平、腹膜细胞学检查结果、腹水情况、肿瘤组织学类型、肿瘤分级、最大肿瘤直径、肿瘤细胞减灭术成功率、总生存期和无病生存期与转移性淋巴结数量（<4个与≥4个）的关系。
切除淋巴结的平均数量为24.5个，转移性淋巴结的平均数量为6.2个。约47.3%（n = 155）的患者转移性淋巴结<4个，其余52.7%（n = 173）的患者转移性淋巴结≥4个。两组的单因素比较显示，术前Ca-125值、腹膜细胞学检查结果和临床疾病分期在两组之间存在显著差异。然而，多因素分析显示高Ca-125水平（≥500 IU/l）是两组之间唯一有显著差异的因素。生存分析也未发现两组在总生存期和无病生存期方面存在显著差异。
转移性淋巴结数量随着术前Ca-125值的升高而增加。其他患者特征对转移性淋巴结数量没有显著影响。转移性淋巴结数量在总生存期或无病生存期方面均无预后意义。需要前瞻性系列研究才能得出明确结论。
