尸僵患者肝脏和肌肉酶活性的变化。

Changes of liver and muscle enzymes activity in patients with rigor.

作者信息

Sevastos Nikolaos, Manesis Emanuel K, Savvas Savvas P, Galiatsatos Nikolaos, Papatheodoridis George V, Archimandritis Athanasios J

机构信息

2nd Department of Internal Medicine, National University of Athens Medical School, Hippokration General Hospital, 114 Vas. Sophias ave., 11527 Athens, Greece.

出版信息

Eur J Intern Med. 2008 Mar;19(2):109-14. doi: 10.1016/j.ejim.2007.05.013. Epub 2008 Jan 10.

DOI:10.1016/j.ejim.2007.05.013

PMID:18249306

Abstract

AIM

We investigated whether changes of liver and muscle enzymes activity are associated with rigor of several causes and have any prognostic significance.

METHODS

Seventy-five patients with rigor were prospectively evaluated. Serum enzymes were measured at the onset of rigor and during the three following days.

RESULTS

Causes of rigor were bacteremia (n=28), cholangiitis (n=12), protozoan infections (n=9), viral infections (n=10) and platelet transfusions (n=16). Increases in enzymes activity were observed with rigors from infectious causes, but not with that following platelet transfusions. Patients with cholangiitis demonstrated the highest ALT elevations, while those with viral infections the highest CPK levels. In bacteremia, CPK values increased significantly only in cases with dehydration and hypokalemia.

CONCLUSIONS

Rigor per se does not cause increases in muscle or liver enzymes activities. Rather these changes are associated with the rigor's causative agent (infectious or not), the patient's general condition and the severity and extent of the underlying disease.

摘要

目的

我们研究了肝脏和肌肉酶活性的变化是否与多种原因引起的寒战相关，以及是否具有任何预后意义。

方法

对75例寒战患者进行前瞻性评估。在寒战发作时及随后三天内测定血清酶。

结果

寒战的原因有菌血症（n = 28）、胆管炎（n = 12）、原生动物感染（n = 9）、病毒感染（n = 10）和血小板输注（n = 16）。感染性原因引起的寒战可观察到酶活性升高，但血小板输注后则未观察到。胆管炎患者的ALT升高最为明显，而病毒感染患者的CPK水平最高。在菌血症中，仅在脱水和低钾血症的病例中CPK值显著升高。