Revel Ariel, Revel-Vilk Shoshana
Department of Obstetrics and Gynecology, Hadassah Medical Center and Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Mol Cell Endocrinol. 2008 Jan 30;282(1-2):143-9. doi: 10.1016/j.mce.2007.11.003. Epub 2007 Nov 19.
As the effectiveness of cancer treatments has improved, children diagnosed with cancer can enjoy a longer life free of the disease. However, chemotherapeutic regimens alone or in combination with radiation therapy frequently result in azoospermia or infertility. This paper reviews currently and potentially available methods to maintain fertility in boys undergoing chemotherapy or radiation therapy. Whenever possible, chemotherapeutic agents that are less likely to cause azoospermia, should be considered. Hormonal suppression applied prior to and during chemotherapy may protect future male fertility. Cryopreservation of sperm enables men to reproduce in the future. New techniques, such as in vitro fertilization with intra-cytoplasmic sperm injection offer a more promising future for male cancer sufferers. These techniques however, are not applicable to pre-puberty cancer patients. The use of spermatogonial and embryonic stem cells open new possibilities for boys diagnosed with cancer.
随着癌症治疗效果的提高，被诊断患有癌症的儿童可以享受更长的无病生存期。然而，单独使用化疗方案或与放射治疗联合使用常常会导致无精子症或不育。本文综述了目前以及可能可行的方法，以维持接受化疗或放射治疗男孩的生育能力。只要有可能，就应考虑使用不太可能导致无精子症的化疗药物。化疗前和化疗期间应用激素抑制可能会保护未来男性生育能力。精子冷冻保存使男性能够在未来生育。新技术，如卵胞浆内单精子注射体外受精，为男性癌症患者提供了更有希望的未来。然而，这些技术不适用于青春期前癌症患者。精原干细胞和胚胎干细胞的应用为被诊断患有癌症的男孩开辟了新的可能性。
